TABLE D2. 



INDIVIDUAL ANIMAL TUMOR PATHOLOGY OF FEMALE .MICE IN THE TWO YEAR FEED 

 STUDY OF NITROFURANTOIN: UNTREATED CONTROL 



WEEKS ON 

 STUDY 



CARCASS 



ID 



ALIMENTARY SYSTEM 



Esophagus 



Gallbladder 

 Intestine large 

 Intestine large, cecum 

 Intestine large, colon 

 Intestine large, rectum 

 Intestine small 

 Intestine small, duodenum 

 Intestine small, ileum 



Lymphoma malignant lymphocytic 

 Intestine small, jejunum 



Lymphoma malignant lymphocytic 

 Liver 



Hemangioma 



Hemangiosarcoma 



Hepatocellular carcinoma 



Hepatocellular adenoma 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 

 Mesentery 



Lymphoma malignant lymphocytic 

 Pancreas 

 Salivary glands 



Lymphoma malignant lymphocytic 

 Stomach 



Squamous cell carcinoma 

 Stomach, forestomach 



Papilloma squamous 

 Stomach, glandular 

 Tongue 



Lymphoma malignant lymphocytic 



CARDIOVASCULAR SYSTEM 



Heart 



Hemanposarcoma 



Lymphoma malignant lymphocytic 



ENDOCRINE SYSTEM 



Adrenal gland 

 Adrenal gland, corten 

 Adrenal gland, medulla 



Hepatocellular carcinoma, metastatic, 

 liver 



Pheochromocytoma malignant 



Pheochromocytoma benign 

 Islets, pancreatic 

 Parathyroid gland 

 Pituitary gland 



Pars distalis. adenoma 

 Thyroid gland 



Lymphoma malignant lymphocytic 



Follicular cell, adenoma 



Follicular cell, carcinoma 



GENERAL BODY SYSTEM 

 None 



GENITAL SYSTEM 

 Clitoral gland 

 Ovary 



Cystadenoma. papillary 

 Uterus 



Lymphoma malignant lymphocytic 



Polyp stromal 



+ ; Tissue examined microscopically 



Not examined 

 - : Present but not examined microscopically 

 I: Insufficient tissue 





 2 6 

 2 4 





 9 9 9 



1 3 4 



1 1. 

 9 

 9 2 



"3 T 



3 



1 1 



"T — T" 

 8 

 2 2 



T T 



7 7 

 I 2 



~i 5 3 3 3~ 

 9 6 9 9 

 3 112 3 



"3 — 3 — 3 — 3 — 3~ 

 4 5 5 17 

 12 3 15 



"3 — 3 — T- 

 9 1 2 

 4 2 2 



M + 

 M M 



M M 



A + 



A + 



A + 



A + 



A + 



A -1- 



A + 



M 



+ 

 M 

 -♦- 

 M 



+ + + + 



+ + -F + + 

 + + + <- + 



+ + + 4- + 

 -I- + + -t- + 



+ + 



+ + + + 



+ + + + 



+ + + + 



+ + + + 



+ f •*-+■ + + + 



A A + 



M + M 



+ + + -1- + + +A 

 M + + +MM + + 



+ + + +- + + >• + 



+ + + + + + + +- 



+ +f-f + +- + +- 



+ 4- + -t-+--f- + -t- 



+ +--t- + + -(- + + 



X 



M, Missing 



A; Autolysis precludes examination 



X: Incidence of listed morphology 



Nitrofurantoin, NTP TR 341 



170 



