TABLE CI. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN MALE MICE IN THE TWO-YEAR 



FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



RESPIRATORY SYSTEM 



Lung (50) 



Alveolar/bronchiolar adenoma 5 (10%) 



Alveolar/bronchiolar carcinoma 1 (2%) 



Alveolar/bronchiolar carcinoma, multiple 



Fibrosarcoma, metastatic, stomach 1 (2%) 



Hepatocellular carcinoma, metastatic, liver 1 (2%) 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 3 (6%) 



(50) 

 2 (4%) 

 2 (4%) 



2 (4%) 



(50) 

 4 (8%) 

 2 (4%) 

 I (2%) 



1 (2%) 

 1 (2%) 



SPECIAL SENSES SYSTEM 

 Harderian gland 

 Adenoma 



•(50) 

 2 (4 



•(50) 



3 (6%) 



•(50) 



2 (4%) 



URINARY SYSTEM 

 Kidney 



Fibrosarcoma, metastatic, stomach 

 Lymphoma malignant lymphocytic 

 Lymphoma malignant mixed 



(50) 



I (2%) 

 1 (2%) 



(50) 



(50) 



1 (2%) 



SYSTEMIC LESIONS 

 Multiple organs 



Lymphoma malignant lymphocytic 



Hemangiosarcoma 



Leukemia 



Lymphoma malignant histiocytic 



Lymphoma malignant mixed 



2 (4%) 



(50) 



1 (2%) 



1 (2%) 

 4 (8%) 



ANIMAL DISPOSITION SUMMARY 

 Animals initially in study 

 Dead 



Terminal sacrifice 

 Moribund 



50 



7 



28 



15 



50 



12 



29 



9 



50 



2 



33 



15 



TUMOR SUMMARY 



Total animals with primary neoplasms •* 31 



Total primary neoplasms 52 



Total animals with benign neoplasms 12 



Total benign neoplasms 17 



Total animals with malignant neoplasms 28 



Total malignant neoplasms 35 



Total animals with secondary neoplasms *** 1 



Total secondary neoplasms 5 



27 

 35 

 11 

 15 

 20 

 20 

 2 

 2 



33 

 42 

 14 

 14 

 24 

 28 

 3 

 6 



• Number of animals receiving complete necropsy examinations; all gross lesions including masses examined microscopically. 



*• Primary tumors: all tumors except secondary tumors 



•*• Secondary tumors: metastatic tumors or tumors invasive into an adjacent organ 



141 



Nitrofurantoin, NTP TR 341 



