TABLE D3. 



ANALYSIS OF PRIMARY TUMORS IN FEMALE MICE IN THE TWO-YEAR FEED STUDY 

 OF NITROFURANTOIN (Continued) 



Control 



1,300 ppm 



2,500 ppm 



Thyroid Gland: Follicular Cell Adenoma or Carcinoma 



Overall Rates (a) 



Adjusted Rates (b) 



Terminal Rates (c) 



Day of First Observation 



Life Table Tests (d) 



Logistic Regression Tests (d) 



Cochran-Armitage Trend Test (d) 



Fisher Exact Test (d) 



Overall Rates (a) 



Adjusted Rates (b) 



Terminal Rates (c) 



Day of First Observation 



Life Table Tests (d) 



Logistic Regression Tests (d) 



Cochran-Armitage Trend Test (d) 



Fisher Exact Test(d) 



Hematopoietic System: Lymphoma, 



Overall Rates (a) 



Adjusted Rates (b) 



Terminal Rates (c) 



Day of First Observation 



Life Table Tests (d) 



Logistic Regression Tests (d) 



Cochran-Armitage Trend Test (d) 



Fisher Exact Test(d) 



(a) Number of tumor-bearing animals/number of animals examined at the site 



(b) Kaplan- Meier estimated tumor incidences at the end of the study after adjusting for intercurrent mortality 



(c) Observed tumor incidence at terminal kill 



(d) Beneath the control incidence are the P values associated with the trend test. Beneath the dosed group incidence are the 

 P values corresponding to pairwise comparisons between that dosed group and the controls. The life table analysis regards tu- 

 mors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. The logistic regression test re- 

 gards these lesions as nonfatal. The Cochran-Armitage and Fisher exact tests compare directly the overall incidence rates. 

 A negative trend or lower incidence in a dosed group is indicated by ( N ). 



(e) No P value is reported because no tumors were observed in the 1,300-ppm and control groups. 



Nitrofurantoin, NTP TR 341 



184 



