TABLE 21. 



ABSOLUTE AND RELATIVE LIVER WEIGHTS OF MICE IN THE THIRTEEN-WEEK FEED 

 STUDIES OF NITROFURANTOIN (a) 



(a) Mean ± standard error; P values vs. the i 



(b)P<0.05 



(c)P<0.01 



iintrolsby Dunnett's test i Dunnett, 1955). 



TWO-YEAR STUDIES 



Body Weights, Feed Consumption, and 

 Clinical Signs 



Mean body weights of high dose male mice 

 were 5%-17% lower than those of the controls 

 after week 1 (Table 22 and Figure 11). Mean 

 body weights of high dose female mice were 4%- 

 14% lower than those of the controls from week 

 11 to the end of the study. The average daily 



feed consumption by low dose and high dose 

 male mice was 100% and 95% that by controls 

 (Table G3) and by low dose and high dose 

 female mice, 93% and 96% that by controls 

 (Table G4). The average amount of nitrofuran- 

 toin consumed per day was estimated to be 300 

 mg/kg and 570 mg/kg for low and high dose 

 male mice and 280 mg/kg and 580 mg/kg for 

 low and high dose female mice. Dosed mice had 

 bright yellow urine. 



51 



Nitrofurantoin, NTP TR 341 



