TABLE Bl. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN FEMALE RATS IN THE TWO-YEAR 



FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



NERVOUS SYSTEM 

 Brain 



Astrocytoma malignant 



Carcinoma, metastatic, pituitary gland 



Leukemia mononuclear 



(50) 



(50) 



1 (2%) 

 1 (2%) 

 3 (6%) 



(50) 



1 (2%) 



RESPIRATORY SYSTEM 

 Lung 



Alveolar/bronchiolar adenoma 

 Alveolar/bronchiolar carcinoma 

 Carcinoma, metastatic, thyroid gland 

 Leukemia mononuclear 

 Sarcoma stromal, metastatic, uterus 



SPECIAL SENSES SYSTEM 

 Zymbal gland 

 Carcinoma 



•(50) 



1 (2%) 



•(50) 



1 (2%) 



•(50) 



URINARY SYSTEM 

 Kidney 



Leukemia mononuclear 



Sarcoma stromal, metastatic, uterus 



Renal tubule, adenoma 

 Urinary bladder 



Leukemia mononuclear 



(50) 

 3 (6%) 

 1 (2%) 



(50) 



(50) 

 4 (8%) 



(50) 



1 (2%) 



(50) 

 2 (4%) 



1 (2%) 

 (50) 



1 (2%) 



SYSTEMIC LESIONS 

 Multiple organs 



Leukemia mononuclear 

 Hemangiosarcoma 



•(50) 



9 (18%) 



ANIMAL DISPOSITION SUMMARY 

 Animals initially in study 

 Moribund 

 Terminal sacrifice 

 Dead 



50 



22 



25 



3 



50 

 12 

 26 

 12 



50 



17 



31 



2 



TUMOR SUMMARY 



Total animals with primary neoplasms ** 49 



Total primary neoplasms 109 



Total animals with benign neoplasms 43 



Total benign neoplasms 70 



Total animals with malignant neoplasms 3 1 



Total malignant neoplasms 39 



Total animals with secondary neoplasms *** 1 



Total secondary neoplasms 7 



48 



116 



41 



79 



28 



37 



1 



1 



46 



100 



42 



82 



17 



18 



3 



4 



' Number of animals receiving complete necropsy examinations; all gross lesions including masses examined microscopically. 



'* Primary tumors: all tumors except secondary tumors 



'*• Secondary tumors: metastatic tumors or tumors invasive into an adjacent organ 



113 



Nitrofurantoin, NTP TR 341 



