III. RESULTS: RATS 



Survival 



Estimates of the probabilities of survival for 

 male and female rats fed diets containing nitro- 

 furantoin at the concentrations used in these 

 studies and for controls are shown in Table 10 

 and in the Kaplan and Meier curves in Figure 4. 

 No significant differences in survival were ob- 

 served between any groups of rats of either sex. 



Pathology and Statistical Analyses of 

 Results 



This section describes the statistically signifi- 

 cant or biologically noteworthy changes in the 



incidences of rats with neoplastic or nonneo- 

 plastic lesions of the kidney, parathyroid glands, 

 glandular stomach, bone, subcutaneous tissue, 

 testis, epididymis, preputial gland, clitoral 

 gland, mammary gland, and eye. 



Summaries of the incidences of neoplasms and 

 nonneoplastic lesions, individual animal tumor 

 diagnoses, statistical analyses of primary tu- 

 mors that occurred with an incidence of at least 

 5% in at least one animal group, and historical 

 control incidences for the neoplasms mentioned 

 in this section are presented in Appendixes A 

 and B for male and female rats, respectively. 



TABLE 10. SURVIVAL OF RATS IN THE TWO-YEAR FEED STUDIES OF NITROFURANTOIN 



Control 



fiOO pptii 



1,300 ppm 2,500 ppm 



MALE (a) 



Animals initially in study 



Nonaccidental deaths before termination (bl 



Killed at termination 



Died during termination period 



Survival P values (c) 



FEMALE (a) 



Animals initially in study 



Nonaccidental deaths before termination (bl 



Killed at termination 



Survival P values (c) 



(a) First day of termination period: 730 



(b) Includes animals killed in a moribund condition 



(c)The result of the life table trend test is in the control column, and the results of the life table pairwise comparisons with the 

 controls are in the dosed columns. 



41 



Nitrofurantoin, NTP TR 341 



