TABLE Dl. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN FEMALE MICE IN THE TWO-YEAR 



FEED STUDY OF NITROFURANTOIN 



Untreated Control 



Low Dose 



High Dose 



Animals initially in study 



Animals removed 



Animals examined histopathologically 



50 

 50 

 50 



50 

 50 

 50 



50 

 50 

 50 



ALIMENTARY SYSTEM 



Gallbladder (41) 



Lymphoma malignant histiocytic 

 Intestine large, cecum (43) 



Lymphoma malignant histiocytic 

 Intestme small, ileum 



Lymphoma malignant lymphocytic 

 Intestine small, jejunum 



Lymphoma malignant lymphocytic 

 Liver 



Hemangioma 



Hemangiosarcoma 



Hepatocellular carcinoma 



Hepatocellular adenoma 



Itocell tumor, NOS 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Lymphoma malignant mixed 

 Mesentery '(50) 



Fibrosarcoma 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 3 



Sarcoma 

 Pancreas (47) 



Fibrosarcoma, metastatic, mesentery 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Sarcoma 

 Salivary glands (49) 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 1 



Stomach (49) 



Squamous cell carcinoma 1 



Stomach, forestomach (49) 



Lymphoma malignant lymphocytic 



Papilloma squamous 1 (2%) 



Sarcoma 



Glandular, fibrosarcoma, metastatic, mesentery 

 Stomach, glandular l49) 



Sarcoma 

 Tongue *(50) 



Lymphoma malignant lymphocytic 1 



(6%) 



(2%) 

 (2%) 



(39) 

 (49) 

 (47) 

 (48) 

 (50) 



1 (2%) 



1 (2%) 



1 (2%) 



4 (8%) 



3 (6%) 



3 (6%) 

 •(50) 



1 (2%) 

 (50) 



1 (2%) 

 1 (2%) 

 (50) 



(49) 

 (49) 



1 (2%) 



(49) 



1 (2%) 

 ♦(50) 



(50) 



(50) 

 1 

 1 



1 

 (49) 



♦(50) 



(2%) 

 (2%) 



(2%) 



(2%) 



CARDIOVASCULAR SYSTEM 

 Heart 



Hemangiosarcoma 



Lymphoma malignant lymphocytic 



Sarcoma 



(50) 



1 (2%) 

 1 (2%) 



(50) 



1 (2%) 



(50) 



165 



Nitrofurantoin, NTP TR 341 



