TABLE Dl. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN FEMALE MICE IN THE TWO-YEAR 



FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



NERVOUS SYSTEM 

 Brain 



Lymphoma malignant lymphocytic 

 Meningioma benign 



(49) 



1 (2%) 



(50) 



1 (2%) 



(50) 



1 (2%) 

 1 (2%) 



RESPIRATORY SYSTEM 

 Lung 



Adenocarcinoma, metastatic, mammary gland 



Alveolar/bronchiolar adenoma 



Alveolar/bronchiolar carcinoma 



Basal cell carcinoma, metastatic, skin 



Hepatocellular carcmoma, metastatic, liver 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Lymphoma malignant mixed 



Osteosarcoma, metastatic, bone 



Sarcoma 



Mediastinum, lymphoma malignant lymphocytic 



Mediastinum, sarcoma 



(50) 



2 

 1 



1 

 1 

 3 



(4%) 

 (2%) 



(2%) 

 (2%) 

 (6%) 



3 (6%) 



(50) 



1 (2%) 



2 (4%) 



2 (4%) 

 4 (8%) 

 1 (2%) 

 1 (2%) 

 1 (2%) 



1 (2%) 



(50) 



1 (2%) 

 1 (2%) 



5 (10%) 



6 (12%) 



SPECIAL SENSES SYSTEM 

 Harderian gland 

 Adenocarcinoma 

 Adenoma 



•(50) 



1 (2%) 

 1 (2%) 



•(50) 



1 (2%) 



2 (4%) 



•(50) 



1 (2%) 



URINARY SYSTEM 

 Kidney 



Lymphoma m&lignant histiocytic 

 Lymphoma malignant lymphocytic 

 Lymphoma malignant mixed 

 Sarcoma 



Renal tubule, carcinoma 

 Urinary bladder 



Lymphoma malignant lymphocytic 



(50) 



3 (6% I 



(50) 



1 (2%) 



3 (6%) 



SYSTEMIC LESIONS 

 Multiple organs 

 Hemangioma 



Lymphoma malignant lymphocytic 

 Lymphoma malignant histiocytic 

 Hemangiosarcoma 

 Lymphoma malignant mixed 



4 (8%) 



1 (2%) 



ANIMAL DISPOSITION SUMMARY 

 Animals initially in study 

 Dead 

 Moribund 

 Terminal sacrifice 



50 

 19 

 12 

 19 



50 

 5 

 9 



36 



50 



2 



11 



37 



Nitrofurantoin, NTP TR 341 



168 



