TABLE D4d. HISTORICAL INCIDENCE OF HEPATOCELLL LAR TUMORS IN FEMALE BGCSF, MICE 



RECEIVING NO TREATMENT (a) 



Study 



Adenoma 



Incidence in Controls 



Carcinoma Adenoma or Carcinoma 



Historical Incidence at Southern Research Institute 



HC Blue No. 2 



C.I. Disperse Blue 1 



D-Mannitol 



Ziram 



Eugenol 



Propyl gallate 



Zearalenone 



HC Blue No. 1 



Stannous chloride 



TOTAL 

 SD(b) 



Range (cl 

 High 

 Low 



Overall Historical Incidence 



TOTAL 

 SD(b) 



Range (c) 

 High 

 Low 



(a) Data as of August 7, 1986, for studies of at least 104 weeks 

 (b) Standard deviation 



(c) Range and SD are presented for groups of 35 or more animals. 



(d) One hepatoblastoma was also observed. 



TABLE D4e. HISTORICAL INCIDENCE OF LIVER ITO CELL TUMORS IN FEMALE B6C3F, MICE 



RECEIVING NO TREATMENT (a) 



Diagnosis Incidence in Controls 



Historical Incidence at Southern Research Institute 

 Overall Historical Incidence 



Ito cell tumors 

 Lipomas 



0/447 



0/2,033 



1/2,033 (0.05% I 



(a) Data as of August 7, 1986, for studies of at least 104 weeks 



Nitrofurantoin, NTP TR 341 



188 



