500 



450.0- 



< 



ct: 



O 350.0 



X JOO.O 



o 



>- 

 Q 

 O 



m 



z 

 < 



250.0 



200 0- 



150 



100.0- 



50.0 



. ^ s « ® '^ g 



4^ 



^ i. 



» A 

 A 



r 500 



450 



C- 400.0 



- 350.0 



300.0 



A 



fl 



500 



< 

 a: 

 o 



X 



o 



>- 



Q 

 O 



CD 



Z 

 < 



UJ 



3 



450 0- 



400.0 



350 



300 0- 



250.0 



200 0- 



150 



100 



50.0 



—I — 

 IS 



— I — 

 30 



— I — 

 45 



— I — 

 60 



— I — 

 75 



— 1 — 

 90 



250 



200 



150 



100 



50.0 



105 



WEEKS ON STUDY 





O 



 



A 



n ^ ° - 

 :-" 1 



8- 



8 



\ o 2 



8 X ^ 



Q  A 



 : 



a; 



— I — 



JO 



— I — 

 45 



— I — 

 60 



FEMALE RATS 

  = UNTREATED 

 0=600 PPM 

 A= 1,300 PPM 



— I — 

 75 



— I — 

 90 



500 



450 



400 



350 



300 



250.0 



200 



150.0 



100 



50 



lOS 



WEEKS ON STUDY 



FIGURE 3. GROWTH CURVES FOR RATS FED DIETS CONTAINING 

 NITROFURANTOIN FOR TWO YEARS 



Nitrofurantoin, XTP TR 341 



40 



