TABLE Dl. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN FEMALE MICE IN THE TWO-YEAR 



FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



HEMATOPOIETIC SYSTEM 



Lymph node (Continued) 



Iliac, lymphoma malignant mixed 

 Inguinal, lymphoma malignant histiocytic 

 Inguinal, lymphoma malignant lymphocytic 

 Inguinal, lymphoma malignant mixed 

 Lumbar, lymphoma malignant lymphocytic 

 Mediastinal, lymphoma malignant histiocytic 

 Mediastinal, lymphoma malignant lymphocytic 

 Mediastinal, lymphoma malignant mixed 

 Pancreatic, lymphoma malignant lymphocytic 

 Pancreatic, lymphoma malignant mixed 

 Renal, lymphoma malignant histiocytic 

 Renal, lymphoma malignant lymphocytic 

 Renal, lymphoma malignant mixed 



Lymph node, mandibular 



Lymphoma malignant histiocytic 

 Lymphoma malignant lymphocytic 

 Lymphoma malignant mixed 



Lymph node, mesenteric 



Fibrosarcoma, metastatic, mesentery 

 Lymphoma malignant histiocytic 

 Lymphoma malignant lymphocytic 

 Lymphoma malignant mixed 



Spleen 



Fibrosarcoma, metastatic, mesentery 



Hemangiosarcoma 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Lymphoma malignant mixed 



Thymus 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Lymphoma malignant mixed 



Mediastinum, lymphoma malignant lymphocytic 



1 (2%) 



INTEGUMENTARY SYSTEM 

 Mammary gland 

 Adenoacanthoma 

 Adenocarcinoma 

 Adenocarcinoma, multiple 

 Skin 



Basal cell carcinoma 



Lymphoma malignant lymphocytic 



Squamous cell carcinoma 



Sebaceous gland, adenoma 



Subcutaneous tissue, fibrosarcoma 



Subcutaneous tissue, hemangiosarcoma 



Subcutaneous tissue, schwannoma benign 



(48) 



1 (2%) 



1 (2%) 

 (50) 



1 (2%) 



1 (2%) 

 1 (2%) 



MUSCULOSKELETAL SYSTEM 



Bone 



Osteosarcoma 



Skeletal muscle 



Fibrosarcoma, metastatic, mesentery 

 Lymphoma malignant histiocytic 

 Lymphoma malignant lymphocytic 

 Sarcoma 



(50) 

 •(50) 



1 (2%) 



(50) 



1 (2%) 

 ♦(50) 



1 (2%) 



(50) 



•(50) 



1 (2%) 

 1 (2%) 



167 



Nitrofurantoin, NTP TR 341 



