TABLE CI. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN MALE MICE IN THE TWO-YEAR 



FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



GENITAL SYSTEM 

 Epididymis 



Lymphoma malignant lymphocytic 

 Preputial gland 



Hemangiosarcoma 

 Testes 



Interstitial cell, adenoma, multiple 



(50) 



•(50) 



1 (2%) 

 (49) 



1 (2%) 



(49) 



•(50) 

 (49) 



(50) 



1 (2%) 

 ♦(50) 



(50) 



HEMATOPOIETIC SYSTEM 



Blood •(50) 



Leukemia 1 (2%) 



Bone marrow (50) 



Hemangiosarcoma 1 (2%) 



Lymph node (50) 



Lymphoma malignant lymphocytic 1 (2%) 



Bronchial, lymphoma malignant lymphocytic 1 (2%) 



Bronchial, mediastinal, fibrosarcoma, 

 metastatic, stomach 1 (2%) 



Pancreatic, lymphoma malignant mixed 



Renal, lymphoma malignant lymphocytic 

 Lymph node, mandibular (45) 



Lymphoma malignant lymphocytic 1 (2%) 



Bronchial, mediastinal, alveolar/bronchiolar 

 carcinoma, metastatic, lung 

 Lymph node, mesenteric (47) 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 3 (6%) 



Lymphoma malignant mixed 

 Spleen (50) 



Hemangiosarcoma 1 (2%) 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 4 (8%) 



Lymphoma malignant mixed 

 Thymus (44) 



Lymphoma malignant lymphocytic 2 (5%) 



Mediastinum, fibrosarcoma, metastatic, skin 



♦(50) 

 (50) 

 (49) 



1 (2%) 

 (41) 



(43) 



♦(50) 

 (50) 

 (49) 



1 (2%) 

 (46) 



1 (2%) 

 (44) 



1 (2%) 



2 (5%) 

 (50) 



1 (2%) 



1 (2%) 



2 (4%) 

 (41) 



1 (2%) 



INTEGUMENTARY SYSTEM 



Skin (50) 



Melanoma benign 

 Squamous cell carcinoma 



Subcutaneous tissue, fibroma 1 (2%) 



Subcutaneous tissue, fibroma, multiple 



Subcutaneous tissue, fibrosarcoma 7 (14%) 



Subcutaneous tissue, fibrosarcoma, multiple 2 (4%) 



Subcutaneous tissue, schwannoma malignant 2 (4%) 



Subcutaneous tissue, schwannoma malignant, 

 multiple 1 (2%) 



(50) 



1 (2%) 



1 (2%) 



1 (2%) 



1 (2%) 



5 (10%) 



(50) 



3 (6%) 



11 (22%) 

 1 (2%) 



MUSCULOSKELETAL SYSTEM 

 Skeletal muscle 



Fibrosarcoma, metastatic, stomach 

 Diaphragm, intercostal, alveolar/bronchiolar 

 carcinoma, metastatic, lung 



•(50) 



I (2%) 



•(50) 



•(50) 



1 (2%) 



NERVOUS SYSTEM 

 Brain 



Lymphoma malignant lymphocytic 



(50) 



1 (2%) 



(50) 



(50) 



Nitrofurantoin, NTP TR 341 



140 



