TABLE A5. SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN MALE RATS IN THE 

 TWO-YEAR FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



RESPIRATORY SYSTEM 



Lung (Continued) (50) 



Alveolar epithelium, hyperplasia, focal 

 Alveolar epithelium, hyperplasia, multifocal 

 Alveolus, edema 



Alveolus, mineralization, multifocal 



Arteriole, hypertrophy 1 (2%) 



Bronchiole, foreign body 

 Interstitium, edema 

 Interstitium, infiltration cellular, 



mononuclear cell 

 Interstitium, infiltration cellular, 



histiocytic, diffuse 1 (2% I 



Mediastinum, pigmentation, hemosiderin 

 Nose (50) 



Lumen, foreign body 



Lumen, fungus 2 



Lumen, inflammation, suppurative 3 



Nasolacrimal duct, inflammation, suppurative 1 



(4%) 

 (6%) 

 (2%) 



1 (2%) 

 (49) 



1 (2%) 



1 (2%) 

 4 (8%) 



(50) 



3 (6%) 



1 (2%) 



1 (2%) 



(48) 



1 (2%) 



2 (4%) 



SPECIAL SENSES SYSTEM 



Eye (4) 



Cataract 1 (25%) 



Anterior chamber, hemorrhage 



Anterior chamber, inflammation, suppurative 



Cornea, infiltration cellular, lymphocytic 



Cornea, inflammation, granulomatous, focal 



Cornea, mineralization 



Lens, mineralization 



Retina, degeneration 2 (50%) 



Harderian gland (I) 



Atrophy 



Ectasia 



Fibrosis 1 (100%) 



Lacrimal gland (1) 



Atrophy 1 (100%) 



Inflammation, chronic 1 (100%) 



(5) 



2 (40%) 



3 (60%) 



URINARY SYSTEM 

 Kidney 



Embolus bacterial, multifocal 



Infiltration cellular, lymphocytic, multifocal 



Inflammation, chronic 



Inflammation, suppurative 



Mineralization 



Nephropathy, chronic 



Cortex, cyst 



Cortex, cyst, multiple 



Cortex, necrosis 



Medulla, congestion 



Pelvis, hydronephrosis 



Pelvis, transitional epithelium, hyperplasia 



Renal tubule, hyperplasia, focal 



Renal tubule, pigmentation, hemosiderin 

 Ureter 



Dilatation 

 Urinary bladder 



Mucosa, hyperplasia 



Mucosa, inflammation, chronic 



(50) 



50 (100%) 

 2 (4%) 



1 (2%) 



2 (4%) 

 1 (2%) 



(50) 



(50) 



Nitrofurantoin, NTP TR 341 



108 



