TABLE B5 SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN FEMALE RATS IN THE 

 TWO-YEAR FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



INTEGUMENTARY SYSTEM 

 Mammary gland 

 Hyperplasia, cystic 

 Hyperplasia, lobular 

 Duct, cyst 

 Skin 



Cyst epithelial mclusion 



Hyperkeratosis, focal 



Hyperplasia, focal 



Subcutaneous tissue, cyst 



Subcutaneous tissue, inflammation, suppurative 



MUSCULOSKELETAL SYSTEM 

 Bone 



Osteopetrosis 

 Cranium, hyperostosis 



NERVOUS SYSTEM 

 Brain 



Compression 

 Degeneration, multifocal 

 Hemorrhage, focal 

 Hemorrhage, multifocal 

 Hydrocephalus 



(50) 



1 (2%) 

 3 (6%) 



1 (2%) 



RESPIRATORY SYSTEM 

 Lung 



Angiectasis 



Congestion 



Edema 



Infiltration cellular, lymphocytic, multifocal 



Infiltration cellular, histiocytic, focal 



Inflammation, chronic 



Alveolar epithelium, hyperplasia, focal 



Alveolar epithelium, hyperplasia, multifocal 



Bronchiole, inflammation, chronic active 



Bronchiole, inflammation, suppurative 



Interstitium, edema 

 Nose 



Lumen, foreign body 



Lumen, fungus 



Lumen, inflammation, suppurative 



Nasolacrimal duct, inflammation, suppurative 

 Trachea 



Infiltration cellular, lymphocytic 



(50) 



1 (2%) 



(4%) 

 (8%) 



SPECIAL SENSES SYSTEM 

 Ear 



Middle ear, inflammation, suppurative 

 Eye 



Cataract 



Inflammation, suppurative 



Synechia 



Cornea, edema 



Lens, mineralization 



Retina, degeneration 

 Hardenan gland 



Fibrosis 



Infiltration cellular, lymphocytic, multifocal 



(1) 



1 (100%) 



(18) 



(5) 



(6) 



2 (33%) 



1 (17%) 



2 (33%) 



3 (50%) 



Nitrofurantoin, NTP TR 341 



134 



