TABLE B5. SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN FEMALE RATS IN THE 

 TWO-YEAR FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



GENITAL SYSTEM 

 Clitoral gland 



Inflammation, suppurative 



Duct, cyst 

 Ovary 



Cyst 

 Uterus 



Hemorrhage, chronic, focal 



Hydrometria 



Cervix, abscess 



Cervix, cyst 



Cervix, cyst, multiple 



Cervix, inflammation, suppurative 



Endometrium, cyst 



Endometrium, hyperplasia, cystic 



Endometrium, intlammation, suppurative 



Endometrium, necrosis, focal 



Lumen, inflammation, suppurative 



Muscularis, cyst 



1 (2%) 



(2) 



(48) 



(8) 



1 (13%) 

 (50) 



2 (4%) 

 1 (2%) 

 4 (8%) 



(50) 



1 (2%) 



1 (2%) 



1 (2%) 



1 (2%) 



1 (3%) 

 1 (3%) 



133 



Nitrofurantoin, NTP TR 341 



