V. REFERENCES 



102. Paul, M.F ; Harrington, C. (1967) Nitrofu- 

 rans and enzyme systems of the neonatal ani- 

 mal. Biochem. Pharmacol. 16:2457-2460. 



103. Paul, M.F.; Paul, H.E.; Bender, R C ; Kop- 

 ko, F.; Harrington, CM.; Ells, V.R.; Buzard, J. A. 

 (1960) Studies on the distribution and excretion 

 of certain nitrofurans. Antibiot. Chemother. 

 10:287-302. 



104. Penn, R.G.; Griffin, J. P. (1982) Adverse 

 reactions to nitrofurantoin in the United King- 

 dom, Sweden, and Holland. Br. Med. J. 

 284:1440-1442. 



105. Peterson, F J ; Combs, G.F., Jr.; Holtzman, 

 J.L.; Ma.son, R P (1982a) Metabolic activation of 

 oxygen by nitrofurantoin in the young chick. 

 Toxicol Appl Pharmacol. 65:162-169 



106. Peterson, F.J ; Combs, G F.; Holtzman, J.L.; 

 Mason, R.P (1982b) The effect of selenium and 

 vitamin E deficiency on the toxicity of nitro- 

 furantoin in the chick J Nutr 112:1741-1746. 



107. Preti, M. (1970) Acute toxicities of drugs, 

 solvents, and related compounds in laboratory 

 animals Maffii, G.; Schott, G.; Serralunga, 

 M.G., Eds.: Research Progress in Organic-Bio- 

 logical and Medicinal Chemistry Vol 2 Am- 

 sterdam-London: American Elsevier Publishing 

 Company, p. 302. 



108. Price, C; George, J.; Marr, M. (1985) Tera 

 tologic evaluation of nitrofurazone administered 

 to CD-I mice on gestational days 6-15. National 

 Toxicology Program/Research Triangle Institute 

 Report NTP-85-335. 



109. Prior, J.T.; Ferguson, J.H. (1950) Cytotoxic 

 effects of a nitrofuran on the rat testes. Cancer 

 3:1062-1072. 



110. Pritchard, J. A.; Scott, D.E.; Mason, R.A 

 (1965) Severe anemia with hemolysis and mega- 

 loblastic erythropoiesis J Am. Med. Assoc. 

 194:225-227. 



111. Pugh, D.L.; Olivard, J.; Snyder, H R., Jr ; 

 Heotis, J. P. (1972) Metabolism of l-[(5-nitrofur- 

 furylidene)amino]-2-imidazolidinone. J. Med. 

 Chem. 15:270-273. 



112 Reckendorf, M.K.; Castringlus, R.G.; 

 Spengler, H.K. (1962) Comparative pharmaco- 

 dynamics, urinary excretion, and half-life deter- 

 minations of nitrofurantoin sodium. Antimi- 

 crob Agents Chemother , pp. 531-537. 



113 Rose, GP.; Dewar, A.J.; Stratford, I.J 

 (1982) A biochemical neurotoxicity study relat- 

 ing the neurotoxic potential of metronidazole 

 and nitrofurantoin with misonidazole. Int. J. 

 Rad. Oncol. 8:781-785. 



114. Rosenberg, H.A.; Bates, T R (1976) The in- 

 fluence of food on nitrofurantoin bioavailability 

 Clin. Pharmacol. Ther. 20:227-232 



115. Rosenkranz, H.; Speck, W (1976) Activa- 

 tion of nitrofurantoin to a mutagen by rat liver 

 nitroreductase. Biochem. Pharmacol. 25:1555- 

 1556. 



116. Russo, P.; Pala, M.; Nicolo, G ; Santi, L.; 

 Parodi, S. (1982) DNA damage in liver of rats 

 treated with nitrofurantoin Mutat Res. 

 105:377-382. 



117 Sachs, J.; Geer, T.; Noell, P.; Kunin, CM. 

 (19681 Effect of renal function on urinary re- 

 covery of orally administered nitrofurantoin. N. 

 Engl.J. Med. 278:1032-1035. 



118. Sasaki, M.; Sugimura, K.; Yoshida, M.A.; 

 Abe, S (1980) Cytogenetic effects of 60 chemi- 

 cals on cultured human and Chinese hamster 

 cells. La Kromosomo 11-20:574-584. 



119. Sasame, H.A., Boyd, MR. (1979) Super- 

 oxide and hydrogen peroxide production and 

 NADPH oxidation stimulated by nitrofurantoin 

 in lung microsomes: Possible implications for 

 toxicity. LifeSci 24:1091-1096. 



120. Schirmeister, J ; Stefani, F.; Willmann, H ; 

 Hallauer, W (1965) Renal handling of nitrofu- 

 rantoin in man Antimicrob. Agents Chemo- 

 ther, pp. 223-226. 



121 Setnikar, I ; Magistretti, M.J ; Veronese, M. 

 (1976) Mutagenicity studies on nifurpipone and 

 nitrofurantoin. Proc. Eur. Soc. Toxicol. 17:405- 

 412. 



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