TABLE A4a. HISTORICAL INCIDENCE OF KIDNEY TUBULAR CELL TUMORS IN MALE F344/N RATS 



RECEIVING NO TREATMENT (a) 



Study Incidence of Adenomas or Adenocarcinomas in Controls 



Historical Incidence at Southern Research Institute 



HC Blue No. 2 0/50 



C.I. Disperse Blue 1 0/49 



Eugenol 0/40 



Stannous chloride 0/60 



D-Mannitol 0/50 



Ziram 0/50 



Propyl gallate (b)l/50 



Zearalenone 0/50 



HCBlueNo. 1 (c) 1/50 



TOTAL 2/439(0.5%) 



SD(d) 0.88% 



Range (e) 



High 1/50 



Low 0/50 



Overall Historical Incidence 



TOTAL (f) 8/1,929 (0.4%) 



SD(d) 0.94% 



Range (e) 



High 2/50 



Low 0/50 



(a) Data as of August?, 1986,for studies of at least 104 weeks 



(b) Tubular cell adenoma 



(c) Adenoma, NOS 



(d) Standard deviation 



(e) Range and SD are presented for groups of 35 or more animals. 



(f) Includes one adenoma, NOS, six tubular cell adenomas, and one tubular cell adenocarcinoma 



99 Nitrofurantoin, NTP TR 341 



