III. RESULTS: RATS 



FOURTEEN-DAY STUDIES 



None of the rats died before the end of the stud- 

 ies (Table 6). Rats that received 5,000. 10,000. 

 or 20,000 ppm lost weight, and those that re- 

 ceived 2,500 ppm gained notably less than did 

 the controls. Feed consumption by rats that 



received 5,000, 10,000, or 20,000 ppm was 

 notably less than that by controls during week 1. 

 Compound-related clinical signs included inac- 

 tivity, rough hair coats, sunken eyes, bright yel- 

 low urine, and/or yellow fur. Blue discoloration 

 of the joints was observed in rats that received 

 20,000 ppm. 



TABLE 6. SURVIVAL, MEAN BODY WEIGHTS, AND FEED CONSUMPTION OF RATS 

 FOURTEEN DAY FEED STUDIES OF NITROFURANTOIN 



N THE 



(a) Number surviving/number initially in the group 



(bl Initial group mean body weight ± standard error of the mean 



(c) Mean body weight change of the group ± standard error of the mean 



(d) Grams of feed consumed per animal per day; average of daily determinations; not corrected for scatter. 



Nitrofurantoin, NTPTR341 



36 



