V. REFERENCES 



41 Dunnett, C.W. (1955) A multiple comparison 

 procedure for comparing several treatments 

 with a control. J. Am. Stat. Assoc. 50:1096-1122. 



42. Ebringer, L.; Bencova, M. (1980) Mutagenic- 

 ity of nitrofuran drugs in bacterial systems. 

 Folia Microbiol. (Praha) 25:388-396. 



43. Ebringer, L.; Trubacik, S.; Tuyet, T. (1978) 

 The photocatalytic breakage of nitrofurans and 

 its consequences on Euglena gracilis. Acta 

 F.R.N. Univ. Comen. -Microbiologia 6:1-16. 



44. Epstein, S.S.; Arnold, E.; Andrea, J.; Bass, 

 W.; Bishop, Y. (1972) Detection of chemical mu- 

 tagens by the dominant lethal assay in the 

 mouse. Toxicol. Appi [Pharmacol. 23:288-325. 



45. Fonatsch, C (1977) Effect of nitrofurantoin 

 on meiosis of the male mouse Hum. Genet. 

 39:345-351 



46. Galloway, S.M.; Bloom, A.D., Resnick, M.; 

 Margolin, B.H.; Nakamura, F., Archer, P.; 

 Zeiger, E. (1985) Development of a standard pro- 

 tocol for in vitro cytogenetic testing with Chi- 

 nese hamster ovary cells: Comparison of results 

 for 22 compounds in two laboratories. Environ. 

 Mutagen. 7:1-51 



47. Gart, J.J.; Chu, K.C., Tarone, RE. (1979) 

 Statistical issues in interpretation of chronic 

 bioassay tests for carcinogenicity. J. Natl. 

 Cancer Inst. 62:957-974. 



48. Goldstein, L.I.; Ishak, KG.; Burns, W. (1974) 

 Hepatic injury associated with nitrofurantoin 

 therapy. Am. J. Dig. Dis. 19:987. 



49. Goodman, DR.; Hakkinen, P.J.; Nemenzo, 

 J.H.; Vore, M. (1977) Mutagenic evaluation of 

 nitrofuran derivatives in Salmonella typhimun- 

 um. by the micronucleus test and by in vivo cyto- 

 genetics. Mutat. Res 48:295-306 



50. Haseman, J.K.; Huff, J ; Boorman, G.A. 

 (1984) Use of historical control data in carcino- 

 genicity studies in rodents. Toxicol. Pathol. 

 12:126-135. 



51 Haseman, J K.; Huff, J.; Rao, G.N.; Arnold, 

 J.; Boorman, G.A.; McConnell, E.E. (1985) Neo- 

 plasms observed in untreated and corn oil ga- 

 vage control groups of F344/N rats and 

 (C57BIV6N X C3H/HeN)Fi (B6C3Fi) mice. J. 

 Natl. Cancer Inst. 75:975-984 



52 Hassan, H.M.; Fridovich, I. (1979) Intra- 

 cellular production of superoxide radical and of 

 hydrogen peroxide by redox active compounds. 

 Arch. Biochem Biophys. 196:385-395 



53 Haworth, S., Lawlor, T ; Mortelmans, K.; 

 Speck, W.; Zeiger, E. (1983) Salmonella muta- 

 genicity test results for 250 chemicals. Environ. 

 Mutagen. Suppl 1:3-142. 



54. Iloener, B.-A , Patterson, S.E. (1981) Nitro- 

 furantoin disposition Clin Pharmacol Ther. 

 29:808-816. 



55. International Agency for Research on Cancer 

 (lARC) (1974) 1 ARC .Monographs on the Evalua- 

 tion of the Carcinogenic Risk of Chemicals to 

 Man, Vol. 7 Some Anti Thyroid and Related 

 Substances, Nitrofurans and Industrial Chemi- 

 cals. Lyon: lARC 



56. Ichikawa, M (1978) Chemistry of nitrofuran. 

 Bryan, G.T., Ed.: Carcinogenesis A Compre- 

 hensive Survey, Vol. 4 Nitrofurans: Chemistry, 

 Metabolism, Mutagenesis, and Carcinogenesis. 

 New York: Raven Press, pp. 13-57. 



57. Ishidate, M., Jr.; Hayashi, M., Sawada, M.; 

 Matusoka, A.; Yoshikawa, K.; Ono, M.; .\aka- 

 date, M. (1978) Cytotoxicity test on medical 

 drugs. Chromosome aberration tests with Chi- 

 nese hamster cells in vitro. Eisei Shikenjo Ho- 

 koku (Bull. Natl. Inst. Hyg. Sci. Tokyo) 96:55-61. 



58 Ito, A., Naito, M.; Naito, Y ; Watanabe, H. 

 (1983) Tumorigenicity test of N-(5-nitro-2-fur- 

 furylidene)-l-aminohydantoin by dietary ad- 

 ministration in BDFi mice. Hiroshima J Med. 

 Sci. 31:99-102. 



59. Jonen, H.G.; Kaufman, I. (1980) Enhanced 

 biotransformation of nitrofurantoin in rats after 

 induction with 3-methylcholanthrene or P-naph- 

 thoflavone. Biochem. Pharmacol. 29:263-266. 



Nitrofurantoin, NTP TR 341 



70 



