TABLE A4c. HISTORICAL INCIDENCE OF SUBCUTANEOUS TISSUE TUMORS IN MALE F344/N RATS 



RECEIVING NO TREATMENT (a) 



Incidence in Controls 



Study Fibroma Fibrosarcoma Fibroma or Fibrosarcoma 



Historical Incidence at Southern Research Institute 



HC Blue No. 2 

 C.I. Disperse Blue 1 

 Eugenol 



Stannous chloride 

 D-Mannitol 

 Ziram 



Propyl gallate 

 Zearalenone 

 HC Blue No. 1 



TOTAL 



SD(c) 



Range (d) 

 High 

 Low 



Overall Historical Incidence 



TOTAL 

 SD(c) 



Range (d) 

 High 

 Low 



(a) Data as of August?, 1986, for studies of at least 104 weeks 



(b) Includes one sarcoma, NOS, and one neurofibrosarcoma 



(c) Standard deviation 



(d) Range and SD are presented for groups of 35 or more animals. 



(e) Includes five neurofibromas 



(f) Includes eight sarcomas, NOS, and six neurofibrosarcomas 



101 Nitrofurantoin, NTP TR 341 



