TABLE A4e. HISTORICAL INCIDENCE OF PREPUTIAL GLAND TUMORS IN MALE F344/N RATS 



RECEIVING NO TREATMENT (a) 



Incidence in Controls 



Study Adenoma Carcinoma Adenoma or Carcinoma 



Historical Incidence at Southern Research Institute 



HC Blue No. 2 

 C.I. Disperse Blue 1 

 Eugenol 



Stannous chloride 

 D-Mannitol 

 Ziram 



Propyl gallate 

 Zearalenone 

 HCBlueNo. 1 



TOTAL 

 SD(d) 



Range (e) 

 High 

 Low 



Overall Historical Incidence 



TOTAL (f) 57/1,937 (2.9%) (g)66/l,937(3.4%) (f,g) 123/1,937 (6.4%) 



SD(d) 4.02% 2.93% 4.77% 



Range (e) 



High 8/50 5/50 9/50 



Low 0/50 0/50 0/50 



(a) Data as of August 7, 1986, for studies of at least 104 weeks 



(b) Adenocarcinoma, NOS 



(c) Includes one squamous cell carcinoma 



(d) Standard deviation 



(e) Range and SD are presented for groupsof 35 or more animals. 



(f) Includes one papillary adenoma and one cystadenoma, NOS 



(g) Includes two squamous cell carcinomas, eight adenocarcmomas, NOS, and one sebaceous adenocarcinoma 



103 Nitrofurantoin, NTPTR 341 



