TABLE A4b. HISTORICAL INCIDENCE OF SKELETAL SYSTEM TUMORS IN MALE F344/N RATS 



RECEIVING NO TREATMENT (a) 



Study Incidence of Osteosarcomas in Controls 



Historical Incidence at Southern Research Institute 



HC Blue No. 2 2/50 



C.I. Disperse Blue 1 0/49 



Eugenol 0/40 



Stannous chloride 0/50 



D-Mannitol 1/50 



Ziram 0/50 



Propyl gallate 0/50 



Zearalenone 0/50 



HC Blue No. 1 0/50 



TOTAL 3/439 (0.7%) 



SD(b) 1.41% 



Range (c) 



High 2/50 



Low 0/50 



Overall Historical Incidence 



TOTAL 8/1,937(0.4%) 



SD(b) 0.94% 



Range (c) 



High 2/50 



Low 0/50 



(a) Data asof August 7, 1986, for studies of at least 104 weeks; no osteomas have been observed. 



(b) Standard deviation 



(c) Range and SD are presented for groups of 35 or more animals. 



Nitrofurantoin, NTP TR 341 100 



