TABLE B2. INDIVIDUAL ANIMAL TUMOR PATHOLOGY OF FEMALE RATS IN THE TWO YEAR FEED 



STUDY OF NITROFURANTOIN: LOW DOSE 



WEEKS ON 

 STUDY 



CARCASS 

 ID 



ALIMENTARY SYSTEM 

 Esophapis 

 Intestine large 

 Intestine large, cecum 

 Intestine large, colon 

 Intestine large, rectum 

 Intestine small 

 Intestine small, duodenum 

 Intestine small, ileum 

 Intestine small, jejunum 

 Liver 



Leukemia mononuclear 



Neoplastic nodule 

 Mesentery 

 Pancreas 



Leukemia mononuclear 



Acinus, adenoma 

 Salivary glands 

 Stomach 



Stomach, forestomach 

 Stomach, glandular 

 Tongue 



OOOOOOOOOOOOOOOOOIlllllIl 

 5666778888899999900000000 

 6I36I20116914556923344445 



■3 — 5 — 5 — B — 5" 

 8 2 10 9 

 I 1 1 L I 



CARDIOVASCULAR SYSTEM 

 Heart 

 Leukemia mononuclear 



ENDOCRINE SYSTEM 

 Adrenal gland 

 Adrenal gland, cortex 



Adenoma 



Leukemia mononuclear 

 Adrenal gland, medulla 



Leukemia mononuclear 



Pheochromocytoma benign 

 Islets, pancreatic 

 Parathyroid gland 



Adenoma 

 Pituitary gland 



Leukemia mononuclear 



Pars distalis, adenoma 



Pars distalis. carcinoma 

 Thyroid gland 



Leukemia mononuclear 



C-cell. adenoma 



C-cell, adenoma, multiple 



C eel!, carcinoma 



GENERAL BODY SYSTEM 

 Tissue. NOS 



GENTTAL SYSTEM 

 Clitoral gland 



Adenoma 



Carcinoma 

 Ovary 



Leukemia mononuclear 

 Uterus 



Polyp stromal 



Cervix, squamous cell carcinoma 



Endometnum. sarcoma stromal 



HEMATOPOIETIC SYSTEM 

 Blood 



Leukemia mononuclear 

 Bone marrow 



Leukemia mononuclear 

 Lymph node 



Pancreatic, leukemia mononuclear 

 Lymph node, mandibular 



Leukemia mononuclear 

 Lymph node, mesentenc 



Leukemia mononuclear 

 Spleen 



Leukemia mononuclear 

 Thymus 



"5 — 5 — 5 — 5 — S — 5 — 5 — 5 — 5 5 5 5 5 5 B 5 5 5 5 5~ 

 67125669473898053392 

 112212 32121233222343 



+ M M + 



M + + + 



-t- + + M 



+ + + M 



+ M + M 



+ + + M 



A 



A 

 A 

 A 



A 

 A 

 A 



A 



+ -t- + 



+ ^- + 



+ + + 



+ + + 



■»- + + 

 + -I- + 



-t- + 

 X 



+- + -(- + -f-t- + + +A + + + + 

 ■t- + -(- + + -(- + + + A + + +- + 



X 



X X 



+ 4- + + + + + + +A-t- + -f- + 



X 



+ + + 



+ A + + + + 

 + + + + + + 



X 



+ -♦- + + + 



+ + + + + + -*- + + 



X 



X XXX 



XXX X 



+ -f+' + + -(- + + + + + + 



X 



M M M M 



M +- -t- + M 

 X 



+ 4- 

 X 



X X 



+ M M 



X 



M 



A + 



M M 



Nitrofurantoin, NTP TR 341 



118 



