TABLE B5. SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN FEMALE RATS IN THE 



TWO-YEAR FEED STUDY OF NITROFURANTOIN 



Untreated Control 



Low Dose 



High Dose 



Animals initially in study 



Animals removed 



Animals examined histopathologically 



50 

 50 

 50 



50 

 50 

 50 



50 

 50 

 50 



ALIMENTARY SYSTEM 

 Intestine large, cecum 



Parasite metazoan 



Submucosa, edema, diffuse 



Submucosa, hemorrhage, multifocal 



Submucosa, inflammation, diffuse 

 Intestine large, colon 



Parasite metazoan 



Mucosa, mineralization 

 Intestine large, rectum 



Parasite metazoan 

 Liver 



Angiectasis, focal 



Basophilic focus, multiple 



Clear cell focus 



Cytologic alterations, focal 



Developmental malformation 



Focal cellular change 



Hematopoietic cell proliferation 



Hyperplasia, focal 



Infiltration cellular, lymphocytic, multifocal 



Inflammation, granulomatous, focal 



Inflammation, granulomatous, multifocal 



Necrosis, coagulative, diffuse 



Necrosis, coagulative, focal 



Vacuolization cytoplasmic, diffuse 



Vacuolization cytoplasmic, focal 



Vacuolization cytoplasmic, multifocal 



Bile duct, hyperplasia 



Centrilobular, congestion 



Kupffer cell, pigmentation, bile 

 Mesentery 



Hemorrhage, focal 



Infiltration cellular, lymphocytic 



Inflammation, granulomatous, focal 



Fat, fibrosis, focal 



Fat, necrosis, focal 

 Pancreas 



Acinus, atrophy 



Acinus, atrophy, focal 



Acinus, atrophy, multifocal 



Acinus, hyperplasia, focal 



Duct, cyst 

 Pharynx 



Hyperplasia 



Infiammation, suppurative 

 Stomach 



Inflammation, chronic 

 Stomach, forestomach 



Cyst 



Edema 



Hyperkeratosis 



Hyperplasia 



Inflammation, chronic 



Mineralization 



Ulcer, focal 



Epithelium, hyperplasia 



(50) 



1 (2%) 

 1 (2%) 

 1 (2%) 



(501 



6 (12%) 



(50) 



2 (4%) 



3 (6%) 

 2 (4%) 

 1 (2%) 



(8) 



6 (75%) 

 (50) 



5 (10%) 

 1 (2%) 



1 (2%) 



(50) 



1 (2%) 

 (50) 



3 (6%) 



3 (6%) 



(48) 



1 (2%) 



(46) 



3 (7%) 

 1 (2%) 



(47) 



(50) 



8 (16%) 



4 (8%) 

 1 (2%) 



7 (78%) 



(48) 



5 (10%) 



2 (4%) 



(48) 



1 (2%) 

 (48) 



1 (2%) 

 3 (6%) 



2 (4%) 



2 (4%) 

 1 (2%) 

 1 (2%) 



3 (6%) 



(48) 



1 (2%) 



(48) 

 2 (4%) 



(47) 



1 (2%) 

 (50) 



10 (20%) 



1 (2%) 



1 (2%) 



1 (2%) 



1 (2%) 



1 (2%) 



2 (4%) 

 7 (14%) 



2 (4%) 

 2 (4%) 

 1 (2%) 

 1 (2%) 

 4 (8%) 



(10) 



1 (10%) 



1 (10%) 

 8 (80%) 

 (49) 



1 (2%) 

 8 (16%) 



1 (2%) 



(1) 

 1 (100%) 



1 (100%) 

 (50) 



(50) 



2 (4%) 

 1 (2%) 



1 (2%) 



1 (2%) 

 1 (2%) 



131 



Nitrofurantoin, NTP TR 341 



