TABLE C2. 



INDIVIDUAL ANIMAL TUMOR PATHOLOGY OF MALE MICE IN THE TWO-YEAR FEED 

 STUDY OF NITROFURANTOIN: UNTREATED CONTROL 



WEEKS ON 

 STUDY 



CARCASS 

 ID 



ALIMENTARY SYSTEM 

 Esophagus 



Lvmpnoma malignant lymphocytic 

 Gallbladder 

 Intestine large 

 Intestine large, cecum 

 Intestine large, colon 

 Intestine large, rectum 

 Intestine small 

 Intestine small, duodenum 

 Intestine small, ileum 

 Intestine small, jejunum 

 Liver 



Hemangiosarcoma. multiple 



Hepatocellular carcinoma 



Hepatocellular carcinoma, multiple 



Hepatocellular adenoma 



Hepatocellular adenoma, multiple 



Lymphoma malignant lymphocytic 

 Mesentery 

 Pancreas 

 Salivary glands 

 Stomacn 

 Stomach, forestomach 



Fibrosarcoma 



Squamous cell carcinoma 

 Stomach, glandular 

 Tooth 



CARDIOVASCULAR SYSTEM 



Heart 

 Lymphoma malignant lymphocytic 



ENDOCRINE SYSTEM 



Adrenal gland 

 Adrenal gland, cortex 

 Adrenal gland, medulla 



Pheochromocytoma malignant 



Pheochromocytoma benign 

 Islets, pancreatic 

 Parathyroid gland 

 Pituitary gland 

 Thyroid grand 



Follicular cell, adenoma 



GENERAL BODY SYSTEM 

 None 



GENITAL SYSTEM 



Coagulating gland 

 Epididymis 

 Penis 

 Preputial gland 



Hemangiosarcoma 

 Prostate 

 Seminal vesicle 

 Testes 



Interstitial cell, adenoma, multiple 



~D — (T 

 4 9 

 4 2 



u — or 



1 I 



2 3 



X 



M 



+ ■»-■»- + 

 -*- + ■♦- + 



+ + + + 



+ + + + 



+ + + + 



-(- + + + -*--♦- + + -*- + + 



+ + + + + -*- + + + ■*- + 



■»- + + + + ■*- + + + + + 



+ + + ■(- + + + + + + ■♦- 



+ + + + + + + -f- + + +- 



■t- + -»-+M+ + -*--t- + + 



f -f + + + + 

 X 



+ *- + + + 

 ■♦- + + + ■*- 

 M + + + -t- 



+ -(• + -»-+'■>- 



M M M + + M 



+ M + + + + 



+ M + -t- + M 



+ + f + + 

 + +- + + + 

 + + ■*- + + 



-(- + + -*- + ♦--(- + + + + 



-t--»-M-t- + -»-M + M + + 



-(-■»--*- + -t- + + + -i--*- + 



■t- + -t--t- + 4--(- + + -»- + 



X 



-(- + ■♦-■(-■*- 

 ■•■ + + +-■*- 



+ + 

 X 



+ : Tissue examined microscopically 



Not examined 

 — : Present but not examined microscopically 

 I: Insufficient tissue 



M: Missing 



A: Autolysis precludes examination 



X: Incidence of listed morphology 



Nitrofurantoin, NTP TR 341 



142 



