TABLE C5. SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN MALE MICE IN THE 



TWO-YEAR FEED STUDY OF NITROFURANTOIN 



ENDOCRINE SYSTEM 



Adrenal gland, cortex 

 Hyperplasia, focal 

 Spindle cell, hyperplasia 

 Spindle cell, hyperplasia, focal 



Adrenal gland, medulla 

 Hyperplasia 

 Hyperplasia, focal 



Pituitary gland 



Pars distalis, cyst 



(50) 



1 (2%) 

 5 (10%) 



(49) 

 3 (6%) 

 1 (2%) 



(46) 



(49) 



3 (6%) 



(48) 



6 (13%) 



(48) 



Nitrofurantoin, NTP TR 341 



158 



