TABLE C5. SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN MALE MICE IN THE 

 TWO-YEAR FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



INTEGUMENTARY SYSTEM 

 Skin 



Alopecia 



Alopecia, multifocal 



Fibrosis 



Fungus 



Hyperplasia, focal 



Inflammation, chronic 



Inflammation, granulomatous, focal 



Inflammation, subacute, focal 



Inflammation, suppurative, acute 



Mineralization, focal 



Ulcer 



(50) 

 4 

 3 

 7 



(8%) 

 (6%) 

 (14%) 



1 (2%) 



7 (14%) 

 2 (4%) 

 1 (2%) 



(50) 



5 (10%) 



(50) 

 3 (6%) 



12 (24%) 



1 (2%) 



2 (4%) 



1 (2%) 



9 (18%) 



1 (2%) 



2 (4%) 

 1 (2%) 



MUSCULOSKELETAL SYSTEM 

 Bone 



Cranium, hyperostosis 



(50) 



1 (2%) 



(50) 



(50) 



NERVOUS SYSTEM 

 None 



RESPIRATORY SYSTEM 



Lung 



Congestion 



Fibrosis, multifocal 



Infiltration cellular, histiocytic, multifocal 



Inflammation, subacute, multifocal 



Alveolar epithelium, hyperplasia 



Nose 



Hemorrhage 



(50) 

 3 



32 (64%) 

 1 (2%) 

 (42) 



(50) 



(50) 



SPECIAL SENSES SYSTEM 

 None 



URINARY SYSTEM 

 Kidney 



Calculus gross observation 



Hydronephrosis 



Inflammation, suppurative, acute, multifocal 



Metaplasia, osseous, focal 



Nephropathy 



Cortex, infarct 



Cortex, infarct, focal 



Medulla, mineralization 



Papilla, necrosis 



Renal tubule, degeneration, multifocal 



Renal tubule, dilatation 



Renal tubule, hyperplasia 



Renal tubule, hyperplasia, focal 



Renal tubule, necrosis, multifocal 



Renal tubule, nephropathy 

 Ureter 



Inflammation, suppurative, acute 



1 (2%) 

 (1) 

 1 (100%) 



(50) 



2 (4%) 



1 (2%) 



1 (2%) 



1 (2%) 



1 (2%) 



(50) 



1 (2%) 



1 (2%) 



17 (34%) 



1 (2%) 



14 (28%) 



1 (2%) 



Nitrofurantoin, NTP TR 341 



160 



