TABLE Dl. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN FEMALE MICE IN THE TWO YEAR 



FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



ENDOCRINE SYSTEM 

 Adrenal gland 



Fibrosarcoma, metastatic, mesentery 

 Adrenal gland, cortex 



Adenoma 



Osteosarcoma, metastatic, bone 



Spindle cell, adenoma 

 Adrenal gland, medulla 



Hepatocellular carcinoma, metastatic, liver 



Pheochromocytoma malignant 



Pheochromocytoma benign 

 Islets, pancreatic 



Carcinoma 

 Pituitary gland 



Pars distalis, adenoma 

 Thyroid gland 



Lymphoma malignant lymphocytic 



Follicular cell, adenoma 



Follicular cell, carcmoma 



(50) 

 (50) 



(50) 



(50) 



1 (2%) 

 1 (2%) 

 (49) 



(50) 



(44) 



1 (2%) 

 (49) 



1 (2%) 



(50) 



1 (2%) 

 (50) 



1 (2%) 



(49) 



(49) 



1 (2%) 

 (49) 



2 (4%) 

 (50) 



GENERAL BODY SYSTEM 

 None 



GENITAL SYSTEM 

 Ovary 



Adenoma, tubular 



Cystadenoma 



Cystadenoma, papillary 



Granulosa cell tumor malignant 



Granulosa cell tumor benign 



Hemangioma 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Mixed tumor benign 



Neoplasm, NOS 

 Uterus 



Adenocarcinoma 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Lymphoma malignant mixed 



Polyp stromal 



Sarcoma stromal 



Cervix, lymphoma malignant mixed 



(50) 



2 (4%) 



(50) 



1 (2%) 



2 (4%) 



(50) 



1 (2%) 



3 (6%) 



1 (2%) 



1 (2%) 



(50) 



1 (2%) 



2 (4%) 



1 (2%) 



2 (4%) 



1 (2%) 



HEMATOPOIETIC SYSTEM 



Bone marrow (50) 



Lymphoma malignant lymphocytic 3 (6%) 



Lymph node (50) 



Axillary, lymphoma malignant histiocytic 

 Bronchial, lymphoma malignant histiocytic 

 Bronchial, lymphoma malignant lymphocytic 1 (2%) 



Bronchial, lymphoma malignant mixed 

 Deep cervical, lymphoma malignant lymphocytic 1 (2%) 

 Iliac, lymphoma malignant lymphocytic 



(50) 



(49) 



1 (2%) 

 1 (2%) 

 3 (6%) 



1 (2%) 



Nitrofurantoin, NTP TR 341 



166 



