TABLE D2. 



INDIVIDUAL ANIMAL TUMOR PATHOLOGY OF FEMALE MICE IN THE TWO-YEAR FEED 

 STUDY OF NITROFURANTOIN: HIGH DOSE 



WEEKS ON 

 STUDY 



CARCASS 



ID 



ALIMENTARY SYSTEM 



Esophagus 

 Gallbladder 



Lymphoma cnahgnant histiocytic 

 Intestine large 

 Intestine large, cecum 



Lymphoma malignant histiocytic 

 Intestine large, colon 

 Intestine large, rectum 

 Intestine small 

 Intestine small, duodenum 

 Intestine small, ileum 

 Intestine small, jejunum 

 Liver 



Hepatocellular carcinoma 



Hepatocellular adenoma 



Ito cell tumor. NOS 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 

 Mesentery 



Fibrosarcoma 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Sarcoma 

 Pancreas 



Fibrosarcoma, metastatic, mesentery 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 

 Salivary glands 



Lyrapnoma malignant histiocytic 

 Stomach 

 Stomach, forestomach 



Lymphoma malignant lymphocytic 



Papilloma squamous 



Glandular, fibrosarcoma, metastatic, 

 mesentery 

 Stomach, glandular 



CARDIOVASCULAR SYSTEM 



Heart 



ENDOCRINE SYSTEM 



Adrenal gland 



Fibrosarcoma, metastatic, mesentery 

 Adrenal gland, cortex 



Adenoma 

 Adrenal gland, medulla 

 Islets, pancreatic 



Carcinoma 

 Parathyroid gland 

 Pituitary gland 



Pars distalis, adenoma 

 Thyroid gland 



GENERAL BODY SYSTEM 



None 



GENITAL SYSTEM 



Ovary 



Adenoma, tubular 



Cystadenoma 



Granulosa cell tumor malignant 



Granulosa cell tumor benign 



Hemangioma 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Mixed tumor benign 



Neoplasm, NOS 

 Uterus 



Adenocarcinoma 



Lymphoma malignant histiocytic 



Polyp stromal 



Sarcoma stromal 



I 1 1 

 

 5 5 5 



1 — 3 — 5 — 3 — 5~ 

 4 9 3 6 9 

 11112 



~i — 3~ 



1 2 

 1 1 



T — T" 



7 5 

 1 L 



"3 — T" 



5 7 

 2 2 



T — 3 — 3 — T" 



1111 



2 3 4 5 



"3 — 3 — T" 

 2 3 3 

 5 2 3 



+ M M + M + 



+ + + -*- 

 ■t- + + M 



+ + + ^-■^ + -f + 



+ + + ■♦- + + + -*- 

 X 



+ + + + + + + + 



+ + + + + + + + 



+ + + + ■!- + + + 



+ + + + + + + ■«■ 



+ + + -(- + + + + 



+ + + + + + + + 



+ + + + + + + + 



-♦- + + + 



+ + + + 



+■ + + + 



-)- + + + 



+ + + + 



■I- + + + 



-»- + + + 



X X X X 



-t- ■(- 

 X 



+ + + 



+ + + 

 + + + 



■t- + 



-I- ■»■ 

 + + 



+ ■(- + + 



X X 



X 



+ 4- + 



X X 



X 



f + 



X XX 



+ + + + + + + + 



X 



■I- -»■ 



X X 



Nitrofurantoin, NTP TR 341 



178 



