TABLE D5. 



SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN FEMALE MICE IN THE 

 TWO-YEAR FEED STUDY OF NITROFURANTOIN (Continued) 



L'ntreated Control 



Low Dose 



High Dose 



MUSCULOSKELETAL SYSTEM 

 Skeletal muscle 



Inflammation, suppurative, acute 



(2) 



1 150%) 



(1) 



(2) 



NERVOUS SYSTEM 

 Brain 



Compression 



Hydrocephalus 



Inflammation, suppurative, acute, multifocal 



Necrosis 



(49) 



(50) 



1 (2%) 

 1 (2%) 

 1 (2%) 

 1 (2%) 



(50) 



1 (2%) 



RESPIRATORY SYSTEM 

 Lung 



Congestion 



Hemorrhage, focal 



Infiltration cellular, histiocytic, multifocal 



Inflammation, subacute 



Inflammation, subacute, multifocal 



Inflammation, suppurative, acute 



Alveolar epithelium, hyperplasia 



Mediastinum, inflammation, suppurative, acute 

 Nose 



Hemorrhage 



Inflammation, granulomatous 



Inflammation, suppurative, acute 



SPECIAL SENSES SYSTEM 

 Harderian gland 

 Hemorrhage 



(2) 



(5) 

 1 (20%) 



(1) 



URINARY SYSTEM 

 Kidney 



Cyst 



Fibrosis, focal 



Hydronephrosis 



Metaplasia, osseous, focal 



Nephropathy 



Cortex, infarct 



Cortex, mineralization, diffuse 



Medulla, mineralization 



Renal tubule, degeneration, multifocal 



Renal tubule, dilatation 



Renal tubule, necrosis, multifocal 

 Urinary bladder 



Inflammation, chronic 



(50) 



1 (2%) 



1 (2%) 

 (50) 

 3 (6%) 



1 (2%) 



(50) 



2 (4%) 



(50) 



1 (2%) 



2 (4%) 



1 (2%) 



7 (14%) 



1 (2%) 



1 (2%) 



(50) 



191 



Nitrofurantoin, NTP TR 341 



