TABLE El. MUTAGENICITY OF NITROFURANTOIN IN SALMONELLA TYPHIMURIUM (a) 



(a) Study performed at SRI International The detailed protocol is presented in Haworth et al. (1983). Cells and study com- 

 pound or solvent (dimethy [sulfoxide I were incubated in the absence of exogenous metabolic activation ( -S9) or with Aroclor 

 1254-induced S9 from male Syrian hamster liver or male Sprague Dawley rat liver. High dose was limited by toxicity or 

 solubility but did not exceed 10 mg/plate;() pg/plate dose is the solvent control. 



(b) Revertantsare presented as mean ± standard error from three plates. 



(c) Positive control; 2-aminoanthracene was used on all strains in the presence of S9. In the absence of metabolic activation, 

 4-nitro-ophenylenediamine was used with TA98, sodium azide was used with TAIOO and TA1535, and 9-aminoacridine was 

 used with TA1537. 



(d)Slight toxicity 



Nitrofurantoin, NTP TR 341 



194 



