280 FISH HATCHERY MANAGEMENT 



If it is desirable to administer Terramycin orally for the treatment of sys- 

 temic bacterial diseases of catfish, it should be fed at 2.5-3.5 grams active 

 per 100 pounds of fish per day for 7-10 days. If the fish are being fed ap- 

 proximately 3% of their body weight daily, it is necessary to incorporate 

 83.3-116.7 grams of active Terramycin per 100 pounds of food. Under no 

 circumstances should the treatment time be less than 7 days; 10 days is 

 recommended. 



For the treatment of furunculosis and other systemic bacterial diseases of 

 salmonids, Terramycin should be fed at the rate of 4 grams active in- 

 gredient per 100 pounds of fish per day for 10 days. 



Occasionally, it may be necessary to add Terramycin to small amounts of 

 food. This may be done by mixing an appropriate amount of TM-50, 

 TM-50D, or Terramycin Soluble Powder in a gelatin solution (40 grams 

 gelatin to 1 quart of warm water) and spraying it over the daily food ra- 

 tion. The water-soluble powder concentrate of Terramycin is the easiest 

 form with which to work. This form may be purchased in 4-ounce 

 preweighed packages, each of which contains 25.6 grams of antibiotic. As 

 much as two packages of this form may be dissolved in 1 quart of warm 

 gelatin solution. 



If fry or small fingerlings must be treated, it is possible to combine 1 

 pound of fresh beef liver (run through a blender), 1 pound of meal- type 

 feed, 2 raw eggs, and 2.5 grams of active Terramycin into a dough-like 

 consistency. Refrigerate and feed as needed. 



NITROFURANS 



Nitrofurans are not registered by the Food and Drug Administration. 

 Furazolidone (NF-180, Furox-50) and nitrofurazone (Furacin) are closely 

 related compounds that have been widely used to treat bacterial infections 

 in warm- and cold-blooded animals. They are available in several different 

 formulations, but the most common contain either 11% or 4.59% active 

 ingredient (49.9 grams active ingredient per pound of formulation). 



Furazolidone effectively treats furunculosis and redmouth disease in sal- 

 monids, particularly if these pathogens have developed a resistance to Ter- 

 ramycin or sulfonamides. It is fed at the rate of 2.5-4.5 grams active 

 ingredient per 100 pounds of fish per day for 10 days. However, a slightly 

 different method has been used by some workers who feed at the rate of 

 2.5 grams active ingredient per 100 pounds of fish for 3 days, followed by a 

 20-day course of 1.0 gram active ingredient per 100 pounds of fish. Because 

 furazolidone breaks down rapidly in wet (meat or fish) diets, it should be 

 fed in a dry pelleted feed or mixed fresh for each feeding if a wet diet must 

 be used. 



