Major Events in the Development of the DOE 

 Human Genome Program 



Santa Fe Meeting 



Human Genome Initiative announced 



Pilot projects pursued at national laboratories: 



• Computer modeling and optimization of library ordering strategies; 



• Database management support; 



• Advanced instrumentation and vectors for ordering and sequencing; 



• Isolation of centromere, telomere, and chromosome-specific clones; and 



• Production of large DNA insert libraries of chromosomes 



HERAC Report on the DOE Human Genome Initiative 



Interagency workshops on resources and informatics initiated 



Designation of Lawrence Berkeley Laboratory and Los Alamos National 

 Laboratory as Centers 



Initiative management and program plans finalized 



Special peer review panels for research proposals 

 1988 primary R&D awards 

 Small Business Innovative Research (SBIR) awards 

 DOE/NIH Memorandum of Understanding 



Human Genome Coordinating Committee formed 



Human Genome Management 

 Information System initiated 



1989 primary R&D awards 



SIBR awards 



DOE/NIH Five-Year Plan Workshop 



Program plan update for 1990 



1990 program announcements 



DOE/NIH working groups for informatics, 

 mapping, and ethical issues 



Contractor-Grantee Workshop 

 Large Insert Cloning Workshop 

 Human X Chromosome Workshop 



DOE/NIH Five-Year Plan for 

 the Human Genome Project 



1990 primary R&D awards 

 1986 1987 1988 1989 1990 



