Abstracts: 



Resource Development 



Human Repetitive DNA Sequences for Use as Markers in 

 Mapping the Human Genome 



Esther P. Leetlang. Gui-Lin Wang, Joe M. Gatevvood, and Carl W. Schmid 

 Department of Chemistry. University of CaHfomia, Davis. CA 95616 

 (916)752-3003 



A library of repetitive human DNA sequences was constructed from renatured DNA 

 and subsequently screened with known repeats. Of the 460 clones examined. 267 did 

 not hybridize with any of the known repetitive DNAs. Following preliminary sequence 

 analysis and copy-number determination, ten of the clones were selected for further 

 study. The repetitive DNA clones were used as hybridization probes to isolate lambda 

 phage clones from a genomic library. The base sequence, copy number, genomic 

 arrangement, and evolutionary divergence of the new repeat families are now being 

 analyzed. 



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