Abstracts: 



Sequencing 



Technologies 



Scanning Tunneling Microscopy 



T. L. Ferrell, R. J. Warmack, and Dave Allison 



Health and Safety Research Division, Oak Ridge National Laboratory, 



Oak Ridge, TN 3783 1 



(615) 574-6214, FTS 624-6214 



This project includes the operation and continued development of scanning tunneling 

 microscopes for basic physics research related to health and environmental problems. 

 The primary focus of this research is the use of scanning tunneling microscopes in 

 sequencing the human genome. A scanning tunneling microscope with single-atom 

 resolution is used to image atomic structure on surfaces, to alter atomic positions, and to 

 probe the dynamical phenomena caused by collective electron motion and motion of 

 ions. Development includes extending capabilities to a wider range of materials, to 

 identification of atomic species, and to studies of biological samples. Methodologies are 

 developed for atom-by-atom studies of biological molecules important in understanding 

 the human genome and in providing other applications in surface science. 



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