Continuing Implementation 



The 1987 HER AC report on the Human Genome Initiative provided the broad 

 guidehnes tor OHER's Human Genome Program. Refined management and 

 program plans were prepared in 1988. With the experience and progress now 

 achieved and with participation of the Human Genome Coordinating Committee, 

 program guidelines for DOE Human Genome Program implementation have been 

 updated: 



Short-Term Focus (1-5 Years): 



• Improve by an order of magnitude the efficiency and cost-effectiveness of mapping 

 and sequencing technologies. 



• Rapidly develop a database system for current single chromosome projects. 



• Complete orderings of monochromosomal clone libraries already initiated. 



• Initiate physical mapping of additional chromosomes. 



• Improve and implement methods for infonnation and materials dissemination. 



• Develop a long-term human genome database system. 



• Continue small-scale DNA sequencing as an adjunct to physical mapping, and as a 

 test bed for improved sequencing concepts and technologies. 



• Encourage increased private involvement in all areas of genomics, 



Mid-Term Focus (5-10 Years): 



• Accelerate DNA sequencing as more efficient systems are validated. 



• Continue development of algorithms for interpreting sequence information. 



• Utilize accumulating genome knowledge to improve assessments of individual 

 susceptibility to genetic damage, from both unavoidable environmental agents and, 

 especially, energy by-products. 



• Utilize accumulating genome knowledge to identify the more biologically 

 significant damage sites in chromatin. 



• Elucidate the structure, function, and interaction of the body's macromolecules by 

 complementing DNA sequence information with the national laboratories" unique 

 technologies for structural biology studies. 



Long-Term Focus (10-15 Years): 



• Complete large-scale DNA sequencing and apply interpretative algorithms. 



• Emphasize applications of genome knowledge to prospective and retrospective 

 analysis of individual exposures to low levels of energy-related agents. 



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