X-ray diffraction spectroscopy is a labo- 

 ratory mettiod tor determining ttie folded 

 structure of proteins and otiier biological 

 macromolecules- Parallel computing 

 systems can be used to automate inter- 

 pretation of X-ray diffraction patterns 

 acquired via two-dimensional array sen- 

 sors. 



HPCS: Evaluation of Parallel Systems 



DCRT will obtain a next generation parallel computer 

 that will allow the solution of new computationally inten- 

 sive problems in biomedicine. 



NCRR will assess the efficiency and scalability of 

 emerging massively parallel architectures for Grand 

 Challenge problems. 



NREN: More Connections to the Internet 



NLM will establish Internet connections to 70 to 100 

 additional medical centers. 



NREN: Digital Anatomy Databases 



NLM will create advanced three-dimensional imaging 

 databases for digital anatomy on the Internet by the 

 nation's health professions schools. Workstations to 

 access and display those images will be developed. 



NREN: "Knowbots" for Natural Language Queries 



An operational Knowbot-based database retrieval sys- 

 tem will be deployed at NLM to provide integrated 

 access to over 50 computerized knowledge sources in 

 biomedicine, underpinned by a fully operational Unified 

 Medical Language System that allows users to state sci- 

 entific questions in their own language, and have the 

 answer retrieved and synthesized automatically from 

 multiple databases at multiple sites on the Internet. 



ASIA: Software Development and Hardware 

 Placement 



NCI will expand its advanced software development pro- 

 gram to allow research on a broader range of molecular 

 dynamics, structure-function problems, and structure- 

 assisted drug design. 



NLM will develop and deploy advanced molecular biolo- 

 gy workstations to approximately 1,000 molecular biolo- 

 gy laboratories. 



Through funding of five biomedical High Performance 

 Computing Resource Center (HPCRC) programs at 



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