Two-dimensional clinical images from 

 computed tomography and magnetic 

 resonance imaging underpin modern 

 medical diagnosis. Transmission of 

 these diagnostic images over wide area 

 networks and their reconstruction to 

 form three-dimensional views are impor- 

 tant health care applications of HPCC 

 technologies. 



-"Human genetic linkage analysis to determine the 

 likely position of a disease gene using LINKAGE, 

 a gene linkage analysis program that calculates 

 the probability of the association between a pat- 

 tern of gene inheritance and a disease condition. 

 It is used to analyze family pedigrees based on 

 data obtained from gene probes. 



ASIA: "Visible Human" 



NLM initiated a two-year project to acquire the three- 

 dimensional digital representation of entire human 

 beings at millimeter-level resolution, derived from com- 

 puted tomography, magnetic resonance imaging, and 

 digitized cryosections. This "Visible Human" research 

 data set will become available nationally via the Internet 

 in 1994. 



ASIA: Prototype Program for Retrieving IVIolecular 

 Biology Information 



NLM created a prototype advanced molecular biology 

 information retrieval program that provides integrated 

 access to genetic and protein molecular sequences, and 

 the biomedical literature linked to those sequences. 

 Field testing of the system has begun. 



ASTA: Faster Molecular Analysis and Imaging 

 Algorithms 



NCRR and NLM achieved order of magnitude speedups 

 in several existing molecular analysis algorithms. 



DCRT and NCRR developed new algorithms for regis- 

 tration and rendering of three-dimensional images from 

 two-dimensional clinical images and micrographs. 



ASTA: HIV Research 



Research conducted at NCI's Biomedical 

 Supercomputer Center is increasing the understanding 

 of the human immunodeficiency virus (HIV) that causes 

 AIDS and is helping to design and develop new drugs to 

 combat the deadly disease. NCI researchers have suc- 

 cessfully predicted the secondary structure of the entire 

 9,000 unit HIV virus RNA. NCI and NCRR supercom- 

 puting applications have assisted in the design of new 

 drugs to inhibit HIV replication. 



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