High performance systems under 

 evaluation for biomedical appli- 

 cations 



Location 



Cornell Theory 

 Center 



Vendor 



Kendall Square 

 Research 



Machined ) 



KSH-I (64 



nodes) 



SPl 



C-90 & T3D 



CM200 



CMS 



C2I0 



NREN: UMLS Research 



NLM created and published on CD-ROM a prototype 

 Metathesaurus, Semantic Network, and Information 

 Sources Map as part of the Unified Medical Language 

 Systems research effort to link together computer-based 

 biomedical information resources. These data files sup- 

 port experimentation on advanced systems that trans- 

 late user information requests into multiple access 

 vocabularies. 



NREN: Digital Anatomy Demonstration Project 



NLM initiated a demonstration project that will create a 

 digital anatomy workstation that allows a health profes- 

 sions student to browse three-dimensional images gen- 

 erated by a specialized graphics computer at a distant 

 site. The prototype links the NLM's Learning Center for 

 Interactive Technology in Bethesda to the University of 

 Washington at Seattle via the Internet. 



NREN: Access to Cancer Treatment Guidelines 



NCI implemented remote file access to treatment guide- 

 lines from its PDQ (Physician Data Query) database via 

 the Internet. 



ASTA: Parallel Methods for Biomedical 

 Applications 



NCRR-supported High Performance Computing 

 Resource Centers are evaluating high performance sys- 

 tems for biomedical research applications (see Side 

 Bar). Investigators at these Centers have developed 

 applications including: 



□ Modeling the molecular dynamics of proteins in 

 membranes, in order to enable the study of drug 

 permeability across membranes. This requires 

 simulating approximately 10,000 atoms in a mem- 

 brane patch. 



a Simulating the complex interactions between DNA 

 and protein (specifically Eco Rl, a restriction 

 enzyme). This work won the 1993 Computerworld 

 Smithsonian Award. 



90 



