60 Transactions. 



cyanide, (b) Oo c.c. N ammonia. Calculated for 6B, 4 Zn 

 (CNS) S , 3NH 4 CNS, 10 HCNS, Oo— 3-5 c.c. sulphocyanide. 



(2.) Cinchonine - ammonium - zinc - sulphocyanide : 10c. c. 

 ^ cinchonine required (a) - 5 c.c. N ammonia and 3"0c.c. ::: 

 sulphocvanide, (b) 0o5c.c. N ammonia. Calculated for 4B, 

 3Zn(CNS) 2 , 2NH 4 CNS, 4 HCNS, 05 — 30 c.c. N sulpho- 

 cyanide. 



(3.) Cocaine - ammonium - zinc - sulphocyanide : 20 c.c. ^ 

 cocaine required (a) 05 cc. N ammonia and 2 - 5c.c. :;: N sul- 

 phocyanide, (b) 0"5o c.c. N ammonia. Calculated for 6B, 

 2Zn(CNS) 2 . 3NH 4 CNS, 8 HCNS, 0-5 — 2-5 c.c. N sulpho- 

 cyanide. 



(d.) Alkaloid. 



The precipitate from a known amount of alkaloid was 

 collected on a Gooch crucible, and dried in a vacuum over 

 sulphuric acid. Under these conditions the double salts 

 still persistently retain a trace of water, which was removed 

 by heating to 100°. The weights thus obtained should con- 

 firm those calculated from the formulae, which were derived 

 from the analytical results already given above. 



(1.) Quinine -ammonium -zinc -sulphocyanide : Quinine = 

 (a) 54-6 per cent., (b) 55-0 per cent. Calculated for 6B, 

 4 Zn (CNS)„ 3 NH 4 CNS, 10 HCNS— 55-6 per cent. 



(2.) Cinchonine - ammonium - zinc - sulphocyanide : Cin- 

 chonine = 54-9 per cent. Calculated for 4B, 3Zn(CNS).„ 

 2NH 4 CNS, 4 HCNS— 55-7 per cent, 



(3) Cinchonine-potassium-zinc-sulnhocvanide : Cinchonine 

 = 55-4 per cent. Calculated for 4 B," 3Zn(CNS 2 ), 2 KCNS. 

 4 HCNS— 55-6 per cent. 



(4.) Cocaine - ammonium - zinc -sulphocyanide : This com- 

 pound could not be dried without decomposition. 



Summary and Conclusion. 



1. Whereas many alkaloids give insoluble with ammo- 

 nium- or potassium - sulphocyanide and zinc - sulphate, the 

 double salts of quinine, cinchonine, cinchonidine, and cocaine 

 are the most insoluble in the presence of excess of the 

 reagents. 



2. These double salts are exceedingly complex in their 

 composition, a characteristic of many alkaloidal compounds. 

 Thus, cinchonine - ammonium - zmc - sulphocyanide has the 

 formula, 4 (C 19 H„NX>), 3 Zn (CNS). 2 , 2 NH 4 CNS, 4 HCNS. 

 This corresponds closely with the formula of herepathite or 

 sulphate of iodo-quinine, which mav be written, 4 (C. 10 H 24 N. 2 O 2 ) , 

 3H 2 S0 4 , 2 HI, 4I 2 , + 3 aq. 



* The mean of a large number of closely concordant determinations. 



