500 TRAN SURA NIC ELEMENTS IN THE ENVIRONMENT 



NHALATION 



INGESTION 



69.79% 



30% 



GASTROINTESTINAL 



TRACT 



(18-hr TRANSIT] 



0.21% 



22.65% 



FECES 



DEEP 

 LUNG 

 (3 yr) 



LIVER 

 (40 yr) 



8.5% 



30% 



RETAINED 

 INFINITE) 



THORACIC 

 LYMPH NODES I 



1 



MOBILE 

 (1 yr) 



70% 



RETAINED 

 (INFINITE) 



ABDOMINAL 

 LYMPH NODES 





Fig. 7 Block diagram for modifications to the Stuart, Dionne, and Bail (SDB) model. 

 Fraction from blood to total body is 100%. Biological half-time in total body is 65,000 

 days. 



TR - (D3 + D4 + D5) fuRBAm + fGITBTGIT + foLB^^DLYDL + fTLB^TLYTLNM 



+ fALB'^ALYALNM + fLB'^LYliver + fKB^KYK + -^BYbone (71) 



dt 



= (D3 + D4 + D5) fuRDLAm + fBDLFB - (^A + >^Dl) YDL 



dYTLNM 



dt 



dYTLNR 

 dt 



= fOLTL^DLYDL + ^BJUB - i^A + ^TL) YTLNM 



- flLTL^TLYTLNM + foLTR^DLYDL - '^AYTLNR 



dYALNM 

 dt 



- foLAL^DLYDL + ffiALfB " (^A + '^AL)yALNM 



(72) 

 (73) 

 (74) 

 (75) 



