FiTCHETT. — Physiological Action of Tutin. 



337 



Has evidently died from 



Exp. 9. 

 p jyj Rabbit. Weight, 1-16 kilograms. 



6.0. Gave 6 mlgm. per kilo, by mouth. 

 7.25. Respirations seem more rapid than usual. 

 Next day, 9 a.m. Dead. Rigid, in oposthotonic posture, 

 tutin. 



Exp. 10. 

 P ji Rabbit. Weight, 1-069 kilograms. 



3.6. Gave 17-5 minims of a O'o-per-cent. solution tutin (5 mlgm. per kilo), per os. 

 3.45. Has displayed no symptoms. 

 Next day. Quite normal. . 



Exps. 11, 12. 

 Two guinea-pigs, A and B. Weight of A, 624 grams (Exp. 11) ; weight of B, 684 grams 

 (Exp. 12). To A, gave 2 mlgm. per kilo body-weight ; to B, gave 3 mlgm. per kilo 

 body-weight. 



P.M. 



3.20. Gave to A 4-2 minims of a 0-5-per-cent. solution tutin, under skin of back. 



3.40. Gave to B 7 minims of a 0-5-per-cent. solution tutin, under skin of back. Both 



pigs were placed in the same cage, but B attacked A so viciously that it was 



necessary to separate them. 

 3.50. A seems tremulous. 



3.55. A obviously affected, twitching and starting. 

 4.0. B affected in the same way. 

 4.5. Both in violent and continuous convulsions. 

 4.10. B removed from cage, and 17 minims of a 0-05-per-cent. solution of chloral- hydrate 



injected (equal to 0-011 grams per kilo). 

 4.15. B dead ; killed in 35 minutes. Mouth and nostrils found blocked with sawdust 



from the bottom of the cage. 

 4.15. A still in constant convulsions ; becoming feebler. 

 4.30. A dead ; has continued in constant movement since convulsions appeared ; 



killed in 70 minutes. 



Result. — A killed in 70 minutes by 2 mlgm. per kilo ; B in 35 minutes by 3 mlgm. 

 per kilo. 



Exp. 13. 



Guinea-pig. Weight, 751 grams. 



Feb. 13. Gave 4 minims of 0-5-per-cent. solution tutin (1-5 mlgm. per kilo), per os. 

 Weight, 768 grams. Gave 4 minims of 0-5-per-cent. solution, per os. 



17. 

 19 

 20 

 22 

 24 



824 grams. 



Gave 5-2 minims of a 0-5-per-cent. solution (2 ralgm. per 



Gave 4 minims of 0-5-per-cent. solution, per os. 

 Has displayed no symptoms. 

 Weight, 809 grams. Gave 4 minims of 0-5-per-cent. solution, per os. 



,, 823 grams. Gave 5-5 minims of 0-5-per-cent. solution tutin (2 mlgm. 

 per kilo), per os. 

 No symptoms. 

 Weight, 767 grams. 



kilo), per os. 

 Found dead in the morning. 



Result. — Was able to eliminate 1-5 mlgm. per kilo given every second day, but 

 unable to eliminate 2 mlgm. per kilo in two days. 



In this experiment the influence of the prolonged administration of tutin on the 

 weight of the animal was tested by keeping a second guinea-pig under similar conditions 

 as a control. The weights of the two animals as taken during the course of the experi- 

 ment were as follows : — 



A 



26. 



27. 



Feb. 



13 

 17 

 19 

 22 

 24 

 26 



(Control). 

 Grains. 



595 

 589 

 607 

 627 

 633 



B. 



Grams. 



751 



768 

 824 

 809 

 823 

 767 



Result. — Control gained 38 grams ; tutin animal gained 16 grams. 



