FiTCHETT. — Physiological Action of Tutin. 363 



P.M. 



6. 27. Another nioie marked twitch ; sudden spring, with fore arms bowed, giving 



appearance of trying to cling to the ground ; cat more alarmed and astonished 



at the twitching than in the case of tutin ; cerebrum seems less affected ; 



twitches at the slightest noise — e.g., tap of foot on floor, or turning page of 



note-book. 



6.32. Much more marked twitching ; cat stands in unnatural attitude, afraid to move ; 



every movement causes a sharp spasmodic contraction of muscles ; breathing 

 very rapid. 



6.35. General clonic convulsion, lasting a minute and a half ; no tonic stage noticed ; 

 rose immediately seizure had passed ; stands in unnatural attitude, afraid to 

 move ; twitching of eyelids noticed for first time ; seems quite clear mentally. 



6.40. Very cautiously assumed a sitting-position, on haunches ; continuous twitching ; 

 looks up at once if spoken to ; twitching has not been so general since the con- 

 vulsion, nor is it so easily excited by stamping the foot ; not so much salivation 

 as with tutin ; watching with interest movements of a rabbit in a cage opposite. 



6,50. Twitching only very occasional and slight ; sitting with eyes closed, as if dozing ; 

 breathing normal. 



6.55. Twitching more marked again, and is again easily induced by a sudden noise. 

 7.12. Sitting on haunches, in normal attitude; gives occasional uneasy starts; head 



drawn back quickly, or to one or other side. 

 7.22. Still tmtching a little ; eyes half- closed most of the time ; no sign of pain. 



7. 33. Came to front of cage, and rubbed itself against wires ; then sat down as before ; 



is still disturbed by twitchings of fore limbs and head, but it is slighter than it 



Avas, 

 7.43. Drowsy, but wakes up with a start. 

 8.0. Starts are much less frequent, and very slight. 



8.22. Apparently asleep, sitting on haunches ; no further twitcliing noticed. 

 8.30. Same. 



9.0. Apparently normal. 

 9.35. Same. 

 Next day. Quite recovered. 



Exp. 171. 

 pjyj_ Cat. Weight, 3 kilograms. 



4.38. Received 10 minims of an emulsion of coriamyrtin (3 mlgm. or 1 mlgm. per kilo). 

 4.48. Twitcliing fli-st noticed ; saliva dripping from mouth ; mouth open. 



4.50. Vomited ; breathing greatly exaggerated. 



4.51. Deffficated. 



4.54. Breatliing still rapid ; twitching increases. 



4.56. General convulsion, mostly clonic, lasted 30 seconds ; pupils dilate with each 



twitching. 



5.0. Panting hard and twitching constantly. 



5.1. General tonic and clonic convulsion, emprosthotonos, almost standing on head; 



breathing suddenly became normal after convulsion ; then lay with face pressed 

 on floor, breathing heavily ; minor twitching continues. 



5.7. Clonic convul.sions, chin bent down on chest, limbs spread-eagle on either side ; 



stands in an elongated crouching attitude, pressing forehead against floor ; 

 respirations, 160 per minute. 



5.8. Clonic convulsions, emprosthotonos, pupils return to normal size in intervals. 

 5.10. Another convulsion; pupils dilated, as usual. 



5.11. I 



5 12 ' 



5" 14' '" General convulsions ; intervals very short. 



5!l6*.j 



5.20. During a fit, tail rigidly arched over back ; died in tliis convulsion. Heart in- 

 audible to stethoscope immediately after. 

 P.JI. — Three hours afterwards. Membranes of cord and brain markedly congested ; 

 intestines pale ; heart, right side enlarged, left side contracted ; hjemorrhagic patches in 

 lung ; urinary bladder empty ; gall-bladder moderately full ; uterus contained three 

 foetuses ; pieces of cord and brain fixed in 8 per cent, formal sections, made by paraffiia 

 method. 



Feb. 11. Exp. 173. 



P_5i Rabbit. Weight, 1-264 kilograms. 



4.47. Gave 0-6 grams of a 1-in-I solution chloral-hydrate, per rectum. Slight loss of 



the fluid. 

 4.57. Is amesthetised ; gave 17-1 minims of a 0-5-per-cent. solution of tutin (4 mlgm. 

 per kilo), hypoderlnicallJ^ 



