FiTCHETT. — Physiological Action of Tutin. 339 



Exp. 1(5. 



A.M. Pigeon. Weight, 319 grams. 



10.6. Crave 18-3 minims of 0-5-per-cent. solution tutin in normal saline (17 mlgm. per 

 kilo body-weight), per os. 



10.8. First appearance of symptoms, tremulousness and jerking of head ; sudden slight 

 expansive movements of the wings. 



10.10. General con^n^lsions ; marked opisthotonus; bird turning over and over, head 

 firmly retracted on back, wings widely extended, genei'al convulsive move- 

 ments. 



10.13. Has been no cessation, of convulsive movements since onset ; now becoming more 

 feeble. 



10.21. Movements very feeble ; bird apparently been unconscious since onset. 



10.22. All movements ceased. 



P.M. — Crop opened ; found empty, except for a small amount of grumous fluid con- 

 taining small yellow particles. Sour smell, and distinct acid reaction. No abnormality 

 observed. 



Result. — Death in 16 minutes from 17 mlgm. per kilo. 



Exp. 17. 



Pigeon. 

 JFeb. 7. At 6 p.m. gave 2 mlgm. of a 0-5-per-cent. solution tutin (about 1-5 mlgm. 

 per kilo), per os. At 7.5 p.m., apparently normal. At 10.45 p.m., same. 

 8. Quite normal. Gave 3 mlgm. of a 0-5-per-cent. solution tutin (about 2 mlgm. 

 per kilo), per os. 



10. At 6 p.m. pigeon weighed 396 grams. Gave 5-3 minims of a 0-5-per-cent. 

 solution tutin (4 mlgm. per kilo), per os. 



11. Normal. 



14. Weight, 408 grams. Gave 9-7 minims of a 0-5-per-cent. solution (9 mlgm. 

 per kilo), per os. 



15. Normal. 



17. At 6-3 p.m. weighed 388 grams. Gave 11-8 minims of 0-5-per-cent. solution 

 tutin (9 mlgm. per kilo), per os. 



18. Normal. 



19. Weight, 342 grams. Gave 10-8 minims of 0-5-per-cent. solution tutin 

 (9-5 mlgm. per kilo), per os. 



20. Normal. 



24. Weight, 343 grams. Gave 11-6 minims of 0-5-per-cent. solution tutin (10 mlgm. 

 per kilo), per os. 



25. Normal. 



26. At 6 p.m. weighed 370 grams. Gave 15-4 minims of a 0-5-per-cent. solution 

 tutin (12 mlgm. per kilo), per os. At 6.20 p.m. squatting on floor of cage ; 



very tremulous about head and neck ; blinking repeatedly. 

 ,, 27. Found dead in the morning. 



Result. — No tolerance developed. Death from a dose of 12 mlgm. per kilo. 



Exp. 18. 

 Jan. 28. Pigeon. Weight, 357 grams. 



P.M. 



5.45. Gave 18-2 minims of a 0-5-per-cent. solution tutin in normal saline (15 mlgm. 



per kilo body-weight), per os. 

 7.30. Beyond some dullness and. heaviness, no symptoms. 

 Next day. Quite normal. 



Result. — Recovery from 15 mlgm. per kilo. 



Exp. 19. . 

 P.M. Pigeon. Weight, 374 grams. 



6.7. Intended to give 20-3 minims of a 0-5-per-cent. solution tutin (16 mlgm. per 



kilo body-weight), but a few drops were lost, so gave 5 minims more. 

 6.10. General convulsions; marked extension of wings arui bending- backwards of the 



body, so that the bird rests on its tail. 

 6.12. Lying on back, in constant convulsive movement. 

 <3.16. Dead. 



P. 31. — Crop half-full. No abnormality detected. 



Result. — Death in 9 minutes from a dose of about 16 mlgm. per kilo. 



