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Transactions. 



Art. XXXIII. — A Contribution to our Knowledge of the Physiological Action 



of Tutin* 



By Frank Fitchett, M.D. Edin. 

 [Read before the Otago Institute, 10th November, 1908.] 



A. Historical. 



1. General and descriptive 



2. Botany of the tiitii plant 



3. Work of jjrevious observers 



4. The active principle . . 



B. Original Work. 



1. General action of tutin on mammals — 



(«.) Cats 



(b.) Rabbits 



(c.) Gninea-pigs.. 



2. Action on birds 



3. Action on rejitiles 



4. Action on amphibia . . 



5. Action on fishes — 



(a.) General action 



(b.) Comparison of action of tutin and picrotoxin 



(c.) Effects of tutin hydrolysed by hydrochloric acid 



(d.) Action of alkalies on tutin 



(e.) Influence of " surviving " organs 



6. Action on insects 



7. Action on larvse 



8. Action on molluscs . . 



9. Action on infusoria and amoebae 



10. Action on putrefactive bacteria 



11. Action on yeast 



12. Action on germination of seeds 



13. Action on tissues — 



(a.) Action on primitive protoplasm 



(6.) Ciliated epithelium .. 



(c.) Action on striped muscle and nerve-terminations 



14. Action on the different systems — ■ 



(r/.) i\limentary system . . 



(6.) Hoemopoietic system 



(c.) Circulatory and respiratory systems 



(d.) Urinary system 



(e.) Genital system 



(/.) Nervous system 



ig.) General nutrition 



15. Fate of tutin in the body 



16. Imnnmity or tolerance 



17. Pharmacological relationship of tutin . . 



18. Action of remedies 



19. General summary 

 Protocols of experiments 

 Literature references 



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* Being a thesis presented to the University of Edinburgh, for which the degree of 

 Doctor of Medicine was granted. 



