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and curled itself down as if to sleep, but at once raised its head, opened 

 its mouth, and panted for breath, like a dog on a hot day. It moved its 

 head slowly from side to side in a dazed, stupid way. Seven minutes after 

 the injection, thick, ropy saliva began to pour from the open mouth, the 

 respirations were even more rapid, and were now audible, almost stertorous, 

 and the whole body was shaken with the force of the respiratory effort. 

 The pupils at this stage were moderate. Ten minutes after the injection 

 the animal got up and began to walk cautiously about the hutch, picking 

 its way like a cat crossing a muddy street. Half a minute later it was sud- 

 denly seized with a violent convulsion, which in every respect resembled 

 a typical epileptic fit. The animal fell on its side, and all the muscles of 

 the body were thrown into intense tonic spasm. The head was bent firmly 

 backwards, the back hollowed, the fore and hind limbs rigidly extended, 

 the digits widely separated, the claws extruded. The hairs of the tail 

 became erect, urine and fax-es were shot out with considerable violence, the 

 pupils were widely dilated, respiration entirely ceased, and the nose became 

 cyanosed. This tonic spasm lasted thirty seconds, and was followed by 

 clonic spasms affecting the neck, jaw, limbs, and respiratory muscles, which 

 lasted twenty-five seconds more. As the fit passed off, the pupils contracted, 

 the respirations became deeper and slower, and the nose recovered its normal 

 appearance. An interval of five seconds was followed by another fit like 

 the first, but the tonic stage did not last so long, and the clonic spasms 

 were more marked. Fit succeeded fit in rapid succession. There were no 

 voluntary cries, but the violence of each seizure caused a choking noise as 

 the air was driven through the glottis. Between the fits the pupils always 

 contracted, and they began to dilate just before each convulsion occurred ; 

 during the fit they were dilated to the widest possible extent. This alterna- 

 tion happened so invariably that a commencing dilatation of the pupil could 

 be taken as an indication that a convulsion was imminent. As the animal 

 became exhausted the fits diminished in severity and frequency, the re- 

 spirations became irregular, infrequent, and gasping, and finally death 

 occurred thirty-one minutes after the injection. From the first the animal 

 gave no indication that it suffered any pain, and from the onset of the con- 

 vulsions it was unconscious, without either ear or conjunctival reflex. The 

 temperature at death taken in the rectum was 102-4° Fahr. On fosi mortem 

 examination the right horn of the uterus was found to contain a nearly 

 full-sized foetus, which looked as if it had also been aft'ected with convulsions ; 

 one hind leg was twisted over the other, the right forepaw was behind the 

 right ear, and the claws were extruded. Beyond some small haemorrhages 

 in the lungs and a marked congestion of the brain and cord there was nothing 

 noteworthy. 



In the next experiment (Exp. 2) the dose was reduced to 2 mlgm. per 

 kilo body-weight, 7 mlgm. of tutin being injected under the skin of a cat 

 weighing 3-5 kilograms. The first symptom noticed (ten minutes after the 

 injection) was trembling of the head and fore part of the body. This was 

 followed, fourteen minutes after the injection, by rapid breathing (56 to 

 the quarter-minute) and by salivation. At twenty-one minutes, slight 

 twitching of the eyelids and ears was noticed. At twenty-four minutes 

 the animal defax-ated, discharging a large quantity of ffeces. At twenty- 

 five minutes the twitching, which had been gradually getting more marked 

 and more extensive, was severe. At each attack the pupils dilated, but 

 returned to the normal size when the twitching ceased. The respirations 

 were irregular, exaggerated, and suggestive of the Cheyne-Stokes type. 



