FiTCHETT.^ — Physiological Action of Tutin. S35 



P.M. 



3.9. Lies down again ; twitching of face getting more marked, and extending to 

 shonlders ; each attack of twitching followed by loud " miauing," and, as it 

 gets more marked, by growling ; pupils dilate with each attack. 



3.13. General convulsion lasting one minute ; saliva pouring from mouth ; loud 

 voluntary crying after convulsion ; conjvmctival reflex present, pupils widely 

 dilated ; can see ; respiration laboured ; keeps lying on side. 



3.19. Stands up and looks round cage ; breathing easier ; pupils not so large. 



3.21. Walked to another corner of the cage, and sat down ; looks frightened and 

 uneasy ; has been no twitching for some time ; breathing quite easy, and 

 only a little hurried ; salivation seems to have ceased ; constant loud crj- 

 ing ; pupils moderate. 



3.32. Has been quiet since last note ; looks as if it might recover. 



3.34. Now crying loudly, and showing slight twitching of head. 



3.35. Twitching getting more severe; loud prolonged plaintive cries; sitting up on 



haunches, looking round. 



3.36. Walks across cage with cautious unsteady steps. 



3.40. Twitching getting much more marked and more extensive, as if another general 

 convulsion were about to occur ; loud crying ; whole body tremulous ; re- 

 spiration hurried and exaggerated, panting with mouth open ; put its head 

 into the drinking-bowl, but did not lap ; is restless. 



3.42. Most severe general convulsion, lasting 4^ minutes, then a long-drawn inspira- 



tion. 



3.50. Convulsions have continued almost without interval, but now becoming less 



severe ; much frothing at mouth ; gave a cry in an interval. 



3.51. Choky cries occur in the intervals between the conv\dsions ; respirations ir- 



regular and gasping. 



3.55. A longer interval, with loud crying ; respirations in the interval, 14 to the quarter- 



minute. 

 4.2. Has been in almost continuous convulsive movement, with comparatively 



quiescent intervals of only a few seconds, since 3.43 ; in a longer interval than 



usual attempted to rise, but knocked down again by a convulsion. 

 4.4. Seizures shorter ; intervals longer, about 20 seconds to 5 seconds. 

 4.6. After a more severe convulsion than usual respirations are now very slow, 



irregular, and gasping. 



4.9. No convulsions since last note ; respirations more rapid ; running or swimming 



movement of limbs ; attempts to rise, but knocked down by a convulsion. 

 4.15. Gave a voluntary cry. 



4.20. Continues in constant more or less voluntary movement. Has been no. con- 



vulsive seizure since 4.9 till now. 



4.21. No respiratory or other movement since last fit. Is dead. 



Exp. 4. 

 P.M. Cat. Weight, 2-686 kilograms. 



3.46. 3-4 minims of a 0-5-per-cent. solution tutin (0-375 mlgm. per kilo), injected under 



skin of back. 

 3.58. Defsecated, hard motion, covered it up ; begimiing to swallow ; does not look 



so bright as it did ; is quiet ; no change in pupils ; breathing more marked ; 



beginning to look sleejiy. 

 4.2. Swallo\^ing repeatedly ; looks very sleepJ^ 



4.10. Opening mouth and panting; vomited freely and forcibly, a large quantity 



of stomach-contents being ejected ; micturated. 



4.20. Twitching of eyelids and ears. 



4.30. Has shown twitching of face, head, and neck at short intervals ; " miaus " 



occasionally. 

 4.40. Twitching becoming exaggerated, involving shoulders, fore limbs, and back. 



4.43. General convulsions, severe. 



4.47. Gets up after convulsive movements have gradually subsided. 



4.50. Looks very ill ; sitting on jiaunches ; tremulous breathing exaggerated : 

 answers when spoken to ; twitching beginmng again ; salivating. 



4.56. Respirations 48 to the quarter-minute ; lying quiet. 

 5.15. Twitcliing gettmg more marked; cries after each attack. 

 5.19. Still twitching. 



5.21. Twitching involving more muscles. 



5.30. Twitching getting very marked ; at each attack animal almost springs into the 

 air ; loud crying ; breathing very exaggerated ; opens mouth occasionally, 

 and pants for a few seconds. 



