338 ' Transactions. 



Exp. 14. 

 Giiinea-pig. Weight, 1 lb. Fed up to this morning. 



10.53. C4ave 5 minims of 0-5-per-cent. tutin ; injected into mouth, and fluid was readily- 

 swallowed. 

 10.55. Animal seems quite as usual, though easily frightened. 

 11.0. Same. 



11.10. Still same ; trying to chew straw in cage. 

 11.20. Gave it some wet green grass, which it ate greedily. 

 11.45. Quiescent ; has not eaten much grass ; apparently normal. 



P.M. 

 12.5. Seems still quite normal. Gave other 5 minims in same way (about 3-5 mlgm. per 



kilo). 

 12.20. Stretching-movements (? normal). 

 12.30. Normal. 



12.33. Sudden onset of symptoms ; convulsive movements ; stood on liind legs till fell 

 over backwards ; rushed several times round cage ; then tonic spasm, lying on 

 side ; respii'atory movement increased ; twitching of ears and fore part of 

 body. Then became quiescent, lying still on right side. 

 12.40. Resumed usual sitting-position. 

 12.48. Still quiescent. 



12.50. Moved slowly round several times against dii'cction of a clock. 

 1.3. Another fit began, with twitching of head backwards and upwards ; then running- 

 movements of limbs. It ran to front of cage, got its nose into one of the meshes, 

 and tried, as it were, to run forward rapidly ; then ran towards another corner, 

 but fell on its side, and went into a clonic spasm, moving its fore and hind legs 

 vigorously ; then came a more tonic spasm of whole body ; fine ti'emors ; 

 swallowing and gasping movements ; mouth open. By 1.7 it became quiescent 

 again. 

 1.10. Another fit; lying on side and working its fore and hind legs ; head bent back 



on body, but whole body not rigid. 

 1.15. Still same, but movements slower. 

 1.40. Same condition. 



1.50. Movements continue practically without cessation. 

 1.55. Same. 



2.0. Same, slight cries. 

 2.5. Same. 



2.15. Movements less frequent. 

 2.17. Quiescent; dead. 



2.30. Rigor mortis seems to be setting in already. 

 2.45. Rigor distinct. 



P.M. (3.30). — Rigor well marked ; abdomen opened ; some grass observed in 

 stomach and intestines, but no great accumulation of gas. 



Exp. 15. 

 Pigeon. Weight, 314 grams. 



Jan. 14. Gave 2 mlgm. tutin per kilo body- weight, per os. 

 15. No effect, so gave 4 mlgm. per kilo, per os. 



18. No effect, so gave 6 mlgm. per kilo, per os. 



19. Bird seemed dull and heavy for a few hours after the dose ; took no food, and 

 moped in a comer, with feathers puffed out. Is quite well to-day. 



20. Reweighed ; same weight. Gave 8 mlgm. per kilo, per os. 



21. A repetition of symptoms noted pre-\'iously. Is quite well to-day, so gave 

 10 mlgm. per kilo, per os. 



22. Same symptoms as before. Quite well to-day, so gave 12 mlgm. per kilo, per os. 



23. Same symptoms as before. Quite well to-day, so gave 16 mlgm. per kilo, per os. 



24. Same symptoms as before, but quite well to-day ; so at 12 noon gave 20 mlgm. 

 per kilo, per os, on an empty crop. At 12.45 p.m. bird found lying on back in 

 convulsions ; marked retraction of head, and constant movements of feet and 

 flapping of wings. At 12.50 p.m. movements becoming feebler and slower. 

 At 1 p.m. dead ; weight, 345 grams, an increase of 31 grams. 



P.M. — Crop noted to be empty ; nothing abnormal detected. 



Result. — 16 mlgm. per kilo non-lethal ; 20 mlgm. per kilo killed in one hour. 



