4.48. 



FiTCHETT.- — Physiological Action of Tutin. 341 



P.M. 



4.8. Is tremulous and unsteady. 



4.14. Slight convulsive movements, affecting the wings and head ; vomiting. 



4.20. Vomiting. 



4.25. Defecated ; a more severe convulsion ; body bent forward till breast touches 

 ground, head bent back, wings rigidly extended, perhaps one more than the 

 other. The bird was here taken out of the cage and placed on the floor of the 

 laboratory ; it did not attempt to fly away, and kept pretty much to the place 

 where it was set dowia ; it moved away a little if approached. On the whole, 

 seemed more acute mentally than birds that had received a larger dose. 



4.28. Convulsion, but still able to keep its feet ; pupils widely dilated during convul- 

 sion. 



4.33. Retching. 



4.35. I 



4.36. \ Convulsions. 

 4.361 J 



4.38. Vomiting and convulsions. 



4.39. Convulsion, still affecting chiefly the fore part of the body. 

 4.42. Vomiting and convulsions ; pupil continuously dilated. 



4.46. Most severe con\iilsive attack yet, tail involved, and clonic as well as tonic spasm 

 present. The bird was thrown dowTi, but recovered its feet again. 



4.49. Retching. 



4.50. ) 



4.51. Convulsion. 



5.10. Since last note have been frequent convulsions, affecting the neck, wings, and 



tail, but the bird has kept its feet. They are getting more severe, and last 



longer. 

 5.12. Most severe convulsive seizui'e, bird tumbling and somersaulting about the floor 



of the laboratory. 

 5. 14. Lying on back ; all the muscles in constant clonic spasm. 

 5.16. Short interval, during which voluntary squeaking. 



5.20. Lying on back ; convulsions continue ; legs as much affected as wings. 

 5.42. Has been lying on back in constant movement since 5.16. 



5.51. Movements becoming more feeble ; they never entirely disappear, but increase 



in severity at intervals. In the intervals, gasping inspirations. 

 6.2. All movement ceased ; dead. 



Result. — Death in 136 minutes from a dose of 12 mlgm. per kilo. 



Exp. 25. 



P.M. Pigeon (adult). Weight, 386 grams, 



4.45. Gave 15-7 minims of 0-5-per-cent. solution tutin (12 mlgm. per kilo), per os. 



5.30. Lying on back, in continuous convulsive movement. 



5.31. All movement ceased ; dead. 



Result. — Death in 46 minutes from a dose of 12 mlgm. per kilo. 



Exp. 26. 

 P.M. Pigeon (adult). Weight, 305 grams. 



5.52. Gave 9-3 minims of a 0-5-per-cent. solution tutin (9 mlgm. per kilo), per os. 

 Next day, 4 p.m. Quite normal. Displayed no marked symptoms. 



Result. — Recovery from a dose of 9 mlgm. per kilo. 



Exp. 27. 

 P.M. Pigeon (adult). Weight, 365 grams. 



4.30. Gave 11-7 minims of a 0-5-per-cent. solution tutin (9-5 mlgm. per kilo), per os. 

 Next day, 4.30 p.m. Quite normal. Has displayed no marked symptoms. 

 Result. — Recovery from a dose of 9-5 mlgm. per kilo. 



Exp. 28. 

 P.M. Pigeon (young). Weight, 330 grams. 



4.45. Gave 11-2 minims of a 0-5-per-cent. solution tutin (10 mlgm. per kilo), per os. 

 5.10. Lying on back in convulsions. 

 5.30. Dead. 



Result. — Death in 45 minutes from a dose of 10 mlgm. per kilo. 



