FiTCHETT. — Physiological Action of Tutin. 



359 



Exp. 157. 

 A fourth frog, pithed one hour previously. 

 FrogD 



7" 

 6" 



5" 



„ V Movements of lower limbs onlv. 



Average 



6 



6" 



6" 



6" 



6" 



6-1" 



5 minims of a 0-1 -per 

 the skin of the back, and 



Frog D 



cent, solution tutin (10 mlgm. per kilo) was then injected under 

 six minutes later the test reapplied. 



2" Very extensive general movements. 

 Arms moved as well. 



Legs and subsequent movements of arms. 

 Legs, spreading to arms. 

 Legs, arms not moved so vigorously. 

 Both legs only. 



Legs only, response more sluggish. 

 Legs only. 



4" 

 2" 

 1" 

 2" 

 4" 

 5" 

 4" 

 4" 

 2" 



Legs and arms. 



Average 3" 



Exp. 158. 



The experiment was repeated a fifth time. In this case the frog had been pithed 

 in the usual way one hour previously, but it appeared to retain some })ower of voluntary 

 movement, and was so restless that it was suspected that the cerebrum had not been 

 completely destroyed. Extensive general movement followed each application of the 

 acid. 



Left Foot. Right Foot. 



FrogE .. .. .. ..2" 2" 



4" 4" 



3" 4" 



. . 12" 4" 



. . 14" 7" 



.. 11" 8" 



. . 12" 9" 



.. 9" 11" 



8" 6" 



Average 



8-3" 



6-1" 



1 minim of a 0-5 per-cent. solution tutin was then injected (about 12 mlgm. per kilo) 

 under the skin of the back, and 15 minutes later the feet were again dipped into the acid ; 

 but before this was done a typical tutin convulsion occurred. 



Frog G 



Average . . , , . . 22" 



On examination the optic lobes were found to be intact. 



20" 



